Nedd4 Branches Out

被引：8

作者：

DiAntonio, Aaron ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

来源：

NEURON | 2010年 / 65卷 / 03期

关键词：

DEGRADATION; UBIQUITIN; KINASE; GROWTH;

D O I：

10.1016/j.neuron.2010.01.028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The branching of dendrites and axons is a key determinant of neural circuit formation. In this issue of Neuron, Kawabe et al. demonstrate that the ubiquitin ligase Nedd4 promotes the branching of developing dendrites by targeting the small G protein Rap2. In a complementary study, Drinjakovic et al. show that Nedd4 promotes the branching of developing axons by ubiquitinating a different target, the phosphatase PTEN.

引用

页码：293 / 294

页数：2

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