Nedd4 Branches Out

被引：8
|
作者：
DiAntonio, Aaron [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA
来源：
NEURON | 2010年 / 65卷 / 03期
关键词：
DEGRADATION; UBIQUITIN; KINASE; GROWTH;
D O I：
10.1016/j.neuron.2010.01.028
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The branching of dendrites and axons is a key determinant of neural circuit formation. In this issue of Neuron, Kawabe et al. demonstrate that the ubiquitin ligase Nedd4 promotes the branching of developing dendrites by targeting the small G protein Rap2. In a complementary study, Drinjakovic et al. show that Nedd4 promotes the branching of developing axons by ubiquitinating a different target, the phosphatase PTEN.
引用
收藏
页码：293 / 294
页数：2
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