Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

被引：73

作者：

Araki, Atsuko ^{[1
]}

Kawai, Toshio ^{[2
]}

Eitaki, Yoko ^{[2
]}

Kanazawa, Ayako ^{[1
]}

Morimoto, Kanehisa ^{[3
]}

Nakayama, Kunio ^{[3
]}

Shibata, Eiji ^{[4
]}

Tanaka, Masatoshi ^{[5
]}

Takigawa, Tomoko ^{[6
]}

Yoshimura, Takesumi ^{[7
]}

Chikara, Hisao ^{[7
]}

Saijo, Yasuaki ^{[8
]}

Kishi, Reiko ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Publ Hlth Sci, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Japan Ind Safety & Hlth Assoc, Osaka Occupat Hlth Serv Ctr, Nishi Ku, Osaka 5500001, Japan

[3] Osaka Univ, Grad Sch Med, Suita, Osaka 5650871, Japan

[4] Aichi Med Univ, Sch Med, Aichi 4801195, Japan

[5] Fukushima Coll, Fukushima 9600181, Japan

[6] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan

[7] Fukuoka Inst Hlth & Environm Sci, Dazaifu 8180135, Japan

[8] Asahikawa Med Coll, Asahikawa, Hokkaido 0788510, Japan

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2010年 / 408卷 / 10期

关键词：

Microbial volatile organic compounds (MVOC); Exposure; Indoors; Home environment; Sick building syndrome; Mucous membrane; Symptoms; Questionnaires; SICK BUILDING SYNDROME; ENVIRONMENTAL-FACTORS; HOUSE-DUST; ALLERGIC SYMPTOMS; COMPOUNDS MVOCS; EXPOSURE; ASTHMA; GROWTH; ASSOCIATIONS; METABOLITES;

D O I：

10.1016/j.scitotenv.2010.02.012

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Microorganisms are known to produce a range of volatile organic compounds, so-called microbial VOC (MVOC). Chamber studies where humans were exposed to MVOC addressed the acute effects of objective and/or subjective signs of mucosal irritation However, the effect of MVOC on inhabitants due to household exposure is still unclear The purpose of this epidemiological study was to measure indoor MVOC levels in single family homes and to evaluate the relationship between exposure to them and sick building syndrome (SBS) All Inhabitants of the dwellings were given a self-administered questionnaire with standardized questions to assess their symptoms Air samples were collected and the concentrations of eight selected compounds in indoor air were analyzed by gas chromatography/mass spectrometry selective ion monitoring mode (GC/MS-SIM). The most frequently detected MVOC was 1-pentanol at a detection rate of 78 6% and geometric mean of 060 mu g/m(3). Among 620 participants, 120 (19.4%) reported one or more mucous symptoms; irritation of the eyes, nose, airway, or coughing every week (weekly symptoms), and 30 (4 8%) reported that the symptoms were home-related (home-related symptoms). Weekly symptoms were not associated with any of MVOC. whereas significant associations between home-related mucous symptoms and 1-octen-3-ol (per log(10)-unit: odds ratio (OR) 5 6, 95% confidence interval (Cl) 21 to 14.8) and 2-pentanol (per log(10)-unit OR 2.3, 95% CI 1 0 to 4.9) were obtained after adjustment for gender, age, and smoking. Associations between home-related symptoms and 1-octen-3-ol remained after mutual adjustment. However, concentrations of the selected compounds in indoors were lower than the estimated safety level in animal studies. Thus, the statistically significant association between 1-octen-3-ol may be due to a direct effect of the compounds or the associations may be being associated with other offending compounds. Additional studies are needed to evaluate these possibilities. (C) 2010 Elsevier B.V. All rights reserved

引用

页码：2208 / 2215

页数：8

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