Developmental Origins of Adult Disease

被引:174
|
作者
Langley-Evans, Simon C. [1 ]
McMullen, Sarah [1 ]
机构
[1] Univ Nottingham, Sch Biosci, Nottingham NG7 2RD, England
基金
美国国家卫生研究院;
关键词
Programming; Nutrition; Cardiovascular disease; Metabolic syndrome; LOW-PROTEIN-DIET; SYSTOLIC BLOOD-PRESSURE; CORONARY-HEART-DISEASE; INTRAUTERINE GROWTH-RETARDATION; MATERNAL NUTRIENT RESTRICTION; GLUCOSE-INSULIN METABOLISM; NEONATAL LEPTIN TREATMENT; REDUCED FETAL-GROWTH; LOW-BIRTH-WEIGHT; JUNK FOOD DIET;
D O I
10.1159/000273066
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Variation in the quality or quantity of nutrients consumed during pregnancy can exert permanent and powerful effects upon the developing fetus. This programming of fetal development is emerging as a new risk factor for non-communicable diseases of adulthood, including coronary heart disease and the metabolic syndrome. Epidemiological studies show that indicators of nutritional deficit in pregnancy are associated with greater risk of diabetes and cardiovascular mortality. The study of programming in relation to disease processes has been advanced by the development of animal models, which have utilized both under- and over-feeding of specific nutrients in pregnancy. Studies of this nature support the nutritional programming hypothesis and provide tools with which to examine the mechanisms through which programming may occur. Studies of animals subject to undernutrition in utero generally exhibit changes in the structure of key organs, such as the kidney and pancreas. These effects are consistent with the concept that programming influences remodel the development of organs. The causal pathways which extend from tissue remodelling to disease processes are relatively well characterised. In contrast, the processes which drive disordered organ development are poorly understood. It is noteworthy that minor perturbation of maternal nutritional status can programme fetal development. It is suggested therefore that programming is a product of altered expression of key genes. This drives the tissue remodelling response and future disease risk. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码:87 / 98
页数:12
相关论文
共 50 条
  • [31] Developmental Origins of Sex Differences in Adult Mood
    Seney, Marianne
    NEUROPSYCHOPHARMACOLOGY, 2017, 42 : S83 - S84
  • [32] CHARACTERIZING THE DEVELOPMENTAL ORIGINS OF THE ADULT BLOOD SYSTEM
    Patel, Sachin
    Camargo, Fernando
    EXPERIMENTAL HEMATOLOGY, 2018, 64 : S92 - S92
  • [33] From Developmental Origins of Adult Disease to Life Course Research on Adult Disease and Aging: Insights from Birth Cohort Studies
    Power, Chris
    Kuh, Diana
    Morton, Susan
    ANNUAL REVIEW OF PUBLIC HEALTH, VOL 34, 2013, 34 : 7 - 28
  • [34] The Reproduction of Shame: Pregnancy, Nutrition and Body Weight in the Translation of Developmental Origins of Adult Disease
    Moore, Vivienne
    Warin, Megan
    SCIENCE TECHNOLOGY & HUMAN VALUES, 2022, 47 (06) : 1277 - 1301
  • [35] Integration of physiological and molecular mechanisms of the developmental origins of adult disease: new concepts and insights
    Symonds, Michael E.
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2007, 66 (03) : 442 - 450
  • [36] Life-long echoes - A critical analysis of the developmental origins of adult disease model
    Gluckman, PD
    Hanson, MA
    Morton, SMB
    Pinal, CS
    BIOLOGY OF THE NEONATE, 2005, 87 (02): : 127 - 139
  • [37] Developmental origins of health and disease (DOHaD)
    Silveira, Patricia P.
    Portella, Andre K.
    Goldani, Marcelo Z.
    Barbieri, Marco A.
    JORNAL DE PEDIATRIA, 2007, 83 (06) : 494 - 504
  • [38] Common phenotypes and the developmental origins of disease
    McMullen, Sarah
    Swali, Angie
    CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2013, 16 (04): : 398 - 404
  • [39] Epigenetics and the developmental origins of lung disease
    Joss-Moore, Lisa A.
    Albertine, Kurt H.
    Lane, Robert H.
    MOLECULAR GENETICS AND METABOLISM, 2011, 104 (1-2) : 61 - 66
  • [40] Periconceptional environment and the developmental origins of disease
    Velazquez, Miguel A.
    Fleming, Tom P.
    Watkins, Adam J.
    JOURNAL OF ENDOCRINOLOGY, 2019, 242 (01) : T33 - T49