Enteric Microbiota-Gut-Brain Axis from the Perspective of Nuclear Receptors

被引：23

作者：

Duszka, Kalina ^{[1
]}

Wahli, Walter ^{[2
,3
]}

机构：

[1] Univ Vienna, Dept Nutr Sci, Althanstr 14, A-1090 Vienna, Austria

[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, 11 Mandalay Rd, Singapore 308232, Singapore

[3] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 08期

关键词：

nuclear receptors; microbiota; metabolism; xenobiotics; ARYL-HYDROCARBON RECEPTOR; PREGNANE-X-RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; VITAMIN-D-RECEPTOR; NF-KAPPA-B; INFLAMMATORY-BOWEL-DISEASE; ALPHA PPAR-ALPHA; PROLIFERATOR-ACTIVATED RECEPTORS; MESSENGER-RIBONUCLEIC-ACID; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS;

D O I：

10.3390/ijms19082210

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota-gut-brain axis.

引用

页数：59

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