Gut Microbiota of Nonalcoholic Fatty Liver Disease

被引：42
作者：
Abdou, Reham M. [1 ]
Zhu, Lixin [1 ,2 ]
Baker, Robert D. [1 ]
Baker, Susan S. [1 ]
机构：
[1] SUNY Buffalo, Women & Childrens Hosp Buffalo, Dept Pediat, Digest Dis & Nutr Ctr, 219 Bryant St, Buffalo, NY 14222 USA
[2] 3435 Main St,413 Biomed Res Bldg, Buffalo, NY 14214 USA
来源：
DIGESTIVE DISEASES AND SCIENCES | 2016年 / 61卷 / 05期
基金：
美国国家卫生研究院;
关键词：
NAFLD; NASH; Steatosis; Inflammation; Fibrosis; Microbiota and intestinal permeability; INFLAMMATORY-BOWEL-DISEASE; DISTAL ULCERATIVE-COLITIS; RANDOMIZED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; HEPATIC STELLATE CELLS; BILE-ACID METABOLISM; TOLL-LIKE RECEPTORS; PARENTERAL-NUTRITION; COLONIC-MUCOSA; URIC-ACID;
D O I：
10.1007/s10620-016-4045-1
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.
引用
收藏
页码：1268 / 1281
页数：14
相关论文
共 127 条
[31]   THE FORMATION OF ETHANOL IN ESCHERICHIA-COLI [J].
DAWES, EA ;
FOSTER, SM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1956, 22 (02) :253-265
[32]   Dysbiosis Contributes to Fibrogenesis in the Course of Chronic Liver Injury in Mice [J].
De Minicis, Samuele ;
Rychlicki, Chiara ;
Agostinelli, Laura ;
Saccomanno, Stefania ;
Candelaresi, Cinzia ;
Trozzi, Luciano ;
Mingarelli, Eleonora ;
Facinelli, Bruna ;
Magi, Gloria ;
Palmieri, Claudio ;
Marzioni, Marco ;
Benedetti, Antonio ;
Svegliati-Baroni, Gianluca .
HEPATOLOGY, 2014, 59 (05) :1738-1749
[33]   Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine [J].
de Wit, Nicole ;
Derrien, Muriel ;
Bosch-Vermeulen, Hanneke ;
Oosterink, Els ;
Keshtkar, Shohreh ;
Duval, Caroline ;
de Vogel-van den Bosch, Johan ;
Kleerebezem, Michiel ;
Muller, Michael ;
van der Meer, Roelof .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 303 (05) :G589-G599
[34]   Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice [J].
Devkota, Suzanne ;
Wang, Yunwei ;
Musch, Mark W. ;
Leone, Vanessa ;
Fehlner-Peach, Hannah ;
Nadimpalli, Anuradha ;
Antonopoulos, Dionysios A. ;
Jabri, Bana ;
Chang, Eugene B. .
NATURE, 2012, 487 (7405) :104-+
[35]   Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis [J].
Ding, Bi-Sen ;
Cao, Zhongwei ;
Lis, Raphael ;
Nolan, Daniel J. ;
Guo, Peipei ;
Simons, Michael ;
Penfold, Mark E. ;
Shido, Koji ;
Rabbany, Sina Y. ;
Rafii, Shahin .
NATURE, 2014, 505 (7481) :97-+
[36]   Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice [J].
Dumas, Marc-Emmanuel ;
Barton, Richard H. ;
Toye, Ayo ;
Cloarec, Olivier ;
Blancher, Christine ;
Rothwell, Alice ;
Fearnside, Jane ;
Tatoud, Roger ;
Blanc, Veronique ;
Lindon, John C. ;
Mitchell, Steve C. ;
Holmes, Elaine ;
McCarthy, Mark I. ;
Scott, James ;
Gauguier, Dominique ;
Nicholson, Jeremy K. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (33) :12511-12516
[37]   Diversity of the human intestinal microbial flora [J].
Eckburg, PB ;
Bik, EM ;
Bernstein, CN ;
Purdom, E ;
Dethlefsen, L ;
Sargent, M ;
Gill, SR ;
Nelson, KE ;
Relman, DA .
SCIENCE, 2005, 308 (5728) :1635-1638
[38]   The abundance and variety of carbohydrate-active enzymes in the human gut microbiota [J].
El Kaoutari, Abdessamad ;
Armougom, Fabrice ;
Gordon, Jeffrey I. ;
Raoult, Didier ;
Henrissat, Bernard .
NATURE REVIEWS MICROBIOLOGY, 2013, 11 (07) :497-504
[39]   Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease [J].
Engstler, Anna Janina ;
Aumiller, Tobias ;
Degen, Christian ;
Duerr, Marion ;
Weiss, Eva ;
Maier, Ina Barbara ;
Schattenberg, Joern Markus ;
Jin, Cheng Jun ;
Sellmann, Cathrin ;
Bergheim, Ina .
GUT, 2016, 65 (09) :1564-+
[40]   Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study [J].
Eslamparast, Tannaz ;
Poustchi, Hossein ;
Zamani, Farhad ;
Sharafkhah, Maryam ;
Malekzadeh, Reza ;
Hekmatdoost, Azita .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 99 (03) :535-542
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