Gut Microbiota of Nonalcoholic Fatty Liver Disease

被引：42

作者：

Abdou, Reham M. ^{[1
]}

Zhu, Lixin ^{[1
,2
]}

Baker, Robert D. ^{[1
]}

Baker, Susan S. ^{[1
]}

机构：

[1] SUNY Buffalo, Women & Childrens Hosp Buffalo, Dept Pediat, Digest Dis & Nutr Ctr, 219 Bryant St, Buffalo, NY 14222 USA

[2] 3435 Main St,413 Biomed Res Bldg, Buffalo, NY 14214 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2016年 / 61卷 / 05期

基金：

美国国家卫生研究院;

关键词：

NAFLD; NASH; Steatosis; Inflammation; Fibrosis; Microbiota and intestinal permeability; INFLAMMATORY-BOWEL-DISEASE; DISTAL ULCERATIVE-COLITIS; RANDOMIZED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; HEPATIC STELLATE CELLS; BILE-ACID METABOLISM; TOLL-LIKE RECEPTORS; PARENTERAL-NUTRITION; COLONIC-MUCOSA; URIC-ACID;

D O I：

10.1007/s10620-016-4045-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.

引用

页码：1268 / 1281

页数：14

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