Gut Microbiota of Nonalcoholic Fatty Liver Disease

被引：42

作者：

Abdou, Reham M. ^{[1
]}

Zhu, Lixin ^{[1
,2
]}

Baker, Robert D. ^{[1
]}

Baker, Susan S. ^{[1
]}

机构：

[1] SUNY Buffalo, Women & Childrens Hosp Buffalo, Dept Pediat, Digest Dis & Nutr Ctr, 219 Bryant St, Buffalo, NY 14222 USA

[2] 3435 Main St,413 Biomed Res Bldg, Buffalo, NY 14214 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2016年 / 61卷 / 05期

基金：

美国国家卫生研究院;

关键词：

NAFLD; NASH; Steatosis; Inflammation; Fibrosis; Microbiota and intestinal permeability; INFLAMMATORY-BOWEL-DISEASE; DISTAL ULCERATIVE-COLITIS; RANDOMIZED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; HEPATIC STELLATE CELLS; BILE-ACID METABOLISM; TOLL-LIKE RECEPTORS; PARENTERAL-NUTRITION; COLONIC-MUCOSA; URIC-ACID;

D O I：

10.1007/s10620-016-4045-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.

引用

页码：1268 / 1281

页数：14

共 127 条

[1] Increased Fructose Consumption Is Associated with Fibrosis Severity in Patients with Nonalcoholic Fatty Liver Disease [J].

Abdelmalek, Manal F. ;

Suzuki, Ayako ;

Guy, Cynthia ;

Unalp-Arida, Aynur ;

Colvin, Ryan ;

Johnson, Richard J. ;

Diehl, Anna Mae .

HEPATOLOGY, 2010, 51 (06) :1961-1971

[2] The natural history of nonalcoholic fatty liver disease: A population-based cohort study [J].

Adams, LA ;

Lymp, JF ;

St Sauver, J ;

Sanderson, SO ;

Lindor, KD ;

Feldstein, A ;

Angulo, P .

GASTROENTEROLOGY, 2005, 129 (01) :113-121

[3] Recognition of pathogen-associated molecular patterns by TLR family [J].

Akira, S ;

Hemmi, H .

IMMUNOLOGY LETTERS, 2003, 85 (02) :85-95

[4] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[5] Randomised clinical trial: the beneficial effects of VSL# 3 in obese children with non-alcoholic steatohepatitis [J].

Alisi, A. ;

Bedogni, G. ;

Baviera, G. ;

Giorgio, V. ;

Porro, E. ;

Paris, C. ;

Giammaria, P. ;

Reali, L. ;

Anania, F. ;

Nobili, V. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2014, 39 (11) :1276-1285

[6] Endotoxin and Plasminogen Activator Inhibitor-1 Serum Levels Associated With Nonalcoholic Steatohepatitis in Children [J].

Alisi, Anna ;

Manco, Melania ;

Devito, Rita ;

Piemonte, Fiorella ;

Nobili, Valerio .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 50 (06) :645-649

[7]

Aller R, 2011, EUR REV MED PHARMACO, V15, P1090

[8] Energy intake is associated with endotoxemia in apparently healthy men [J].

Amar, Jacques ;

Burcelin, Remy ;

Ruidavets, Jean Bernard ;

Cani, Patrice D. ;

Fauvel, Josette ;

Alessi, Marie Christine ;

Chamontin, Bernard ;

Ferrieres, Jean .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2008, 87 (05) :1219-1223

[9] CX3CL1-CX3CR1 Interaction Prevents Carbon Tetrachloride-Induced Liver Inflammation and Fibrosis in Mice [J].

Aoyama, Tomonori ;

Inokuchi, Sayaka ;

Brenner, David A. ;

Seki, Ekihiro .

HEPATOLOGY, 2010, 52 (04) :1390-1400

[10] The gut microbiota as an environmental factor that regulates fat storage [J].

Bäckhed, F ;

Ding, H ;

Wang, T ;

Hooper, LV ;

Koh, GY ;

Nagy, A ;

Semenkovich, CF ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723

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