ortho-Quinone drugs go pro

被引：4

作者：

Pillow, Thomas ^{[1
]}

机构：

[1] Genentech Inc, South San Francisco, CA 94080 USA

来源：

NATURE CHEMISTRY | 2022年 / 14卷 / 07期

关键词：

ANTIBODY; DELIVERY;

D O I：

10.1038/s41557-022-00993-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antibody-mediated delivery of therapeutics has been primarily limited to agents containing amine, alcohol or thiol functional groups. Now, an approach has been developed to create stable and bio-reversible prodrugs that mask ortho-quinones. Drug release requires both protease activation followed by acid-assisted elimination.

引用

页码：719 / 720

页数：2

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