Plasma microRNA-19a as a potential biomarker for esophageal squamous cell carcinoma diagnosis and prognosis

被引：28

作者：

Bai, Yongying ^{[1
,3
]}

Lin, Huayue ^{[1
]}

Fang, Zanxi ^{[1
]}

Luo, Qing ^{[1
,2
]}

Fang, Yizhen ^{[1
]}

Su, Yuanhui ^{[1
]}

Hu, Qing ^{[1
]}

Duan, Hongbing ^{[4
]}

Chen, Falin ^{[5
]}

Zhang, Zhong-Ying ^{[1
,2
]}

机构：

[1] Xiamen Univ, Affiliated Zhongshan Hosp, Ctr Clin Lab, Xiamen, Peoples R China

[2] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen, Peoples R China

[3] Zhejiang Univ, Sch Med, Womens Hosp, Clin Anal Ctr, Hangzhou, Zhejiang, Peoples R China

[4] Xiamen Univ, Affiliated Zhongshan Hosp, Dept Thorac Surg, Xiamen, Peoples R China

[5] Fujian Prov Hosp, Clin Lab Ctr, Fuzhou, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 05期

基金：

中国国家自然科学基金;

关键词：

biomarker; Cyfra21-1; esophageal squamous cell carcinoma; miR-19a; plasma; SURGICAL-TREATMENT; DOWN-REGULATION; TUMOR-MARKERS; CANCER; SERUM; STRATEGIES; MIGRATION; SURVIVAL; TARGET; LIVER;

D O I：

10.2217/bmm-2016-0286

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To investigate whether plasma miR-19a can serve as a biomarker for esophageal squamous cell carcinoma (ESCC) diagnosis and prognosis. Materials & methods: Plasma samples from 89 ESCC, 45 benign lesion patients and 80 healthy controls were subjected to RT-qPCR analyses for miR-19a. In addition, plasma samples from 30 patients were collected before and after surgery for the same analyses. Results: Plasma miR-19a was significantly increased in ESCC patients compared with healthy controls. The sensitivity of miR-19a for early stages of ESCC was 68.09%. Combination of miR-19a and cytokeratin 19 fragment 21-1 (Cyfra21-1) further improved the sensitivity to 78.70%. Moreover, plasma miR-19a level was decreased in patients after surgery. Conclusion: Plasma miR-19a may serve as a potential biomarker that complements Cyfra21-1 in detecting early stages of ESCC.

引用

页码：431 / 441

页数：11

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