Efficient and regioselective synthesis of 2-alkyl-2H-indazoles

被引：52
作者：
Cheung, M [1 ]
Boloor, A [1 ]
Stafford, JA [1 ]
机构：
[1] GlaxoSmithKline, Res Triangle Pk, NC 27709 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 10期
关键词：
D O I：
10.1021/jo0265434
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and regioselective synthesis of 2-methyl-2H-indazoles and 2-ethyl-2H-indazoles using trimethyloxonium tetrafluoroborate or triethyloxonium hexafluorophosphate is reported.
引用
收藏
页码：4093 / 4095
页数：3
相关论文
共 12 条
  • [1] Auwers K. V., 1920, CHEM BER, V53, P1211
  • [2] FURAZANS AND FURAZAN OXIDES .1. INTERCONVERSIONS OF ANTHRANILS, BENZOFURAZAN OXIDES, AND INDAZOLES
    BALASUBRAHMANYAM, SN
    RADHAKRISHNA, AS
    BOULTON, AJ
    KANWOON, T
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (05) : 897 - 901
  • [3] The structure of the nitrioindazoles and thetr N-methyl derivatives
    Barclay, IM
    Campbell, N
    Dodds, G
    [J]. JOURNAL OF THE CHEMICAL SOCIETY, 1941, : 113 - 118
  • [4] SYNTHESIS OF SUBSTITUTED PYRAZOLO[3,4-B]PHENOTHIAZINE AND PYRAZOLO[4,3-C]PHENOTHIAZINE DERIVATIVES
    BOYER, G
    GALY, JP
    BARBE, J
    [J]. HETEROCYCLES, 1995, 41 (03) : 487 - 496
  • [5] BOYER JH, 1986, J CHEM RES-S, P416
  • [6] 2-substituted indazoles from electrogenerated ortho-nitrosobenzylamines.
    Frontana-Uribe, BA
    Moinet, C
    [J]. TETRAHEDRON, 1998, 54 (13) : 3197 - 3206
  • [7] METHYLATION OF INDAZOLES AND RELATED REACTIONS
    JAFFARI, GA
    NUNN, AJ
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (20): : 2371 - 2374
  • [8] SYNTHETIC STUDIES ON CHEMOTHERAPEUTICS .3. SYNTHESIS OF 6,9-DIHYDRO-9-OXO-1H AND 2H-PYRAZOLO[3,4-F]QUINOLINE-8-CARBOXYLIC ACID-DERIVATIVES [STUDIES ON SYNTHESES OF HETEROCYCLIC-COMPOUNDS .718.]
    KAMETANI, T
    KIGASAWA, K
    HIIRAGI, M
    WAKISAKA, K
    KUSAMA, O
    SUGI, H
    KAWASAKI, K
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (07) : 1175 - 1182
  • [9] A synthesis of 9-methoxy-1-methyl-1H,6H-pyrazolo[4,3-c]carbazole
    Morel, S
    Boyer, G
    Coullet, F
    Galy, JP
    [J]. SYNTHETIC COMMUNICATIONS, 1996, 26 (13) : 2443 - 2447
  • [10] PERST H, 1995, ENCY REAGENTS ORGANI, V7, P5105
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