Hypertension and cognitive function: Pathophysiologic effects of hypertension on the brain

被引:116
|
作者
Manolio, TA [1 ]
Olson, J [1 ]
Longstreth, WT [1 ]
机构
[1] NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA
关键词
D O I
10.1007/s11906-003-0029-6
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Accumulating evidence supports a causal role of hypertension for cognitive decline above and beyond its relationship to frank stroke. Hypertension-associated pathologic changes in the brain and its vasculature include vascular remodeling, impaired cerebral autoregulation, cerebral microbleeds, white matter lesions, unrecognized lacunar infarcts, and Alzheimer-like changes such as amyloid angiopathy and cerebral atrophy. White matter lesions and retinal vascular changes, both of which can be imaged noninvasively, may reveal the general condition of the cerebral vasculature or the presence of arteriosclerotic or hypertensive encephalopathy. These noninvasive indicators may also identify a subgroup in whom infarct prevention, particularly via blood pressure reduction, is of paramount importance. Optimal control of blood pressure on a population-wide basis, but particularly in those prone to cognitive loss, is thus a critically important but as yet elusive goal that should be fully exploited for its potential to reduce future cognitive impairment.
引用
收藏
页码:255 / 261
页数:7
相关论文
共 50 条
  • [21] Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review
    Yang, Wei
    Luo, Hongyu
    Ma, Yixin
    Si, Sicong
    Zhao, Huan
    AGING AND DISEASE, 2021, 12 (03): : 841 - 851
  • [22] PATHOPHYSIOLOGIC FEATURES OF HYPERTENSION IN YOUNG MEN
    DELEEUW, PW
    KHO, TL
    BIRKENHAGER, WH
    CHEST, 1983, 83 (02) : 312 - 314
  • [23] Sleep apnea and hypertension: Pathophysiologic mechanisms
    Richert, A
    Ansarin, K
    Baran, AS
    SEMINARS IN NEPHROLOGY, 2002, 22 (01) : 71 - 77
  • [24] HYPERTENSION IN THE ELDERLY - A PATHOPHYSIOLOGIC APPROACH TO THERAPY
    IZZO, JL
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1982, 30 (05) : 352 - 359
  • [25] HYPERTENSION IN THE AGED - A PATHOPHYSIOLOGIC BASIS FOR TREATMENT
    WEBER, MA
    NEUTEL, JM
    CHEUNG, DG
    AMERICAN JOURNAL OF CARDIOLOGY, 1989, 63 (16): : H25 - H32
  • [26] EFFECTS OF BARORECEPTORS ON THE BRAIN AND HYPERTENSION
    ELBERT, T
    RAU, H
    DWORKIN, B
    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 1991, 11 (01) : 25 - 25
  • [27] Effects of chronic hypertension on cognitive functioning
    Elias, MF
    GERIATRICS, 1998, 53 : S49 - S52
  • [28] Correlation between hypertension and cognitive function in elderly
    Fitri, F. I.
    Rambe, A. S.
    1ST INT CONF ON TROP MED & INFECT DIS FAC OF MED UNIV SUMATERA UTARA IN CONJUNCTION WITH THE 23RD NATL CONGRESS OF THE INDONESIAN SOC OF TROP & INFECT DIS CONSULTANT AND THE 18TH ANNUAL MEETING OF INTERNAL MED DEPT FAC OF MED UNIV SUMATERA UTARA, 2018, 125
  • [29] COGNITIVE FUNCTION AND OVERWEIGHT IN PATIENTS WITH HYPERTENSION: ARE THEY LINKED?
    Krotova, V.
    Khomazyuk, T. A.
    JOURNAL OF HYPERTENSION, 2017, 35 : E325 - E326
  • [30] Arterial stiffness and cognitive function in essential hypertension
    Paglieri, C.
    Bisbocci, D.
    Rabbia, F.
    Genesia, M. L.
    Cerrato, P.
    Perozzo, P.
    Saglio, E.
    Testa, E.
    Monticone, S.
    Magnino, C.
    Veglio, F.
    JOURNAL OF HYPERTENSION, 2007, 25 : S169 - S169