Management of atopic dermatitis: a narrative review

被引:40
作者
Goh, Michelle S. Y. [1 ,2 ]
Yun, Jenny S. W. [1 ,3 ]
Su, John C. [4 ,5 ]
机构
[1] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
[2] St Vincents Hosp Melbourne, Melbourne, Vic, Australia
[3] Royal Melbourne Hosp, Melbourne, Vic, Australia
[4] Monash Univ, Eastern Hlth, Melbourne, Vic, Australia
[5] Murdoch Childrens Res Inst, Melbourne, Vic, Australia
关键词
DIAGNOSTIC-CRITERIA; RISK-FACTORS; ECZEMA; GUIDELINES; CARE; PREVENTION; SKIN; RECOMMENDATIONS; THERAPIES; EMOLLIENT;
D O I
10.5694/mja2.51560
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Atopic dermatitis (atopic eczema) is the most common inflammatory skin disease and has a significant burden on the quality of life of patients, families and caregivers. Its pathogenesis is a complex interplay between genetics and environment, involving impaired skin barrier function, immune dysregulation primarily involving the Th2 inflammatory pathway, itch, and skin microbiome. Restoration of skin barrier integrity with regular emollients and prompt topical anti-inflammatory therapies are mainstays of treatment. Systemic therapy is considered for moderate to severe disease. New understanding of inflammatory pathways and developments in targeted systemic immunotherapies have significantly advanced atopic dermatitis management. Dupilumab is a safe and effective treatment that is now available in Australia. Other promising agents for atopic dermatitis include Janus kinase, interleukin (IL)-13 and IL-31 inhibitors.
引用
收藏
页码:587 / 593
页数:7
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