Real-time tracing the changes in the intracellular pH value during apoptosis by near-infrared ratiometric fluorescence imaging

被引：23
作者：
Lin, Liyun [1 ]
Zhao, Jingjin [1 ]
Zhang, Liangliang [1 ]
Huang, Yong [1 ]
Ye, Fanggui [1 ]
Zhao, Shulin [1 ]
机构：
[1] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 65期
关键词：
CARBON-DOTS; LIVING CELLS; OXIDATIVE STRESS; CANCER-CELLS; SOLAR-CELLS; PROBE; SENSOR; RANGE; NANOPROBES; GREEN;
D O I：
10.1039/c8cc05385e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We developed a near-infrared ratiometric fluorescent nanoprobe with single-excitation dual-emission. The proposed nanoprobe was applied for real-time monitoring the changes in the pH value during hydrogen peroxide-induced apoptosis by ratio imaging. The pH value of HeLa cells changed from 6.6 to 5.6 after H2O2 (100 mu M) stimulation for 40 min.
引用
收藏
页码：9071 / 9074
页数：4
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