Applications of Chiral Squaramides: From Asymmetric Organocatalysis to Biologically Active Compounds

被引：76

作者：

Han, Xin ^{[1
]}

Zhou, Hai-Bing ^{[1
]}

Dong, Chune ^{[1
,2
]}

机构：

[1] Wuhan Univ, Sch Pharmaceut Sci, Minist Educ,State Key Lab Virol, Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL RECORD | 2016年 / 16卷 / 02期

关键词：

applications; asymmetric synthesis; drug discovery; squaramides; CATALYZED CONJUGATE ADDITION; VINYLOGOUS MICHAEL ADDITION; DYNAMIC KINETIC RESOLUTION; ENANTIOSELECTIVE SYNTHESIS; CASCADE REACTION; CINCHONINE-SQUARAMIDE; DERIVATIVES; EFFICIENT; ENONES; ACID;

D O I：

10.1002/tcr.201500266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review seeks to provide coverage on the recent advances in chiral squaramide-catalyzed asymmetric transformations and their applications in the synthesis of a variety of chiral biologically active compounds. It aims to give an overview highlighting the new reaction types and enantioenriched medicinal scaffolds developed in the last few years.

引用

页码：897 / 906

页数：10

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