Analysis of coenzyme Q in human blood and tissues

被引：47

作者：

Barshop, Bruce A. ^{[1
]}

Gangoiti, Jon A. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

来源：

MITOCHONDRION | 2007年 / 7卷

关键词：

coenzyme Q(10); electrochemical detection; tandem mass spectrometry; chromatography;

D O I：

10.1016/j.mito.2007.04.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The major coenzyme Q species in humans is the decaprenyl quinoid derivative coenzyme Q(10) (CoQ(10)), and its measurement is somewhat challenging owing to its hydrophobicity and tendency to be oxidized. There are three major methods which are suited for analysis of CoQ(10): HPLC-coupled UV or electrochemical detection, and tandem mass spectrometry. The techniques are discussed, and results of these applications to determine CoQ(10) concentrations in various human fluids and tissues are summarized. (c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：S89 / S93

页数：5

共 50 条

[21] Cerebellar ataxia and coenzyme Q10 deficiency [J].

Lamperti, C ;

Naini, A ;

Hirano, M ;

De Vivo, DC ;

Bertini, E ;

Servidei, S ;

Valeriani, M ;

Lynch, D ;

Banwell, B ;

Berg, M ;

Dubrovsky, T ;

Chiriboga, C ;

Angelini, C ;

Pegoraro, E ;

DiMauro, S .

NEUROLOGY, 2003, 60 (07) :1206-1208

[22] QUANTITATIVE-DETERMINATION OF VITAMIN-E AND OXIDIZED AND REDUCED COENZYME-Q BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH IN-LINE ULTRAVIOLET AND ELECTROCHEMICAL DETECTION [J].

LANG, JK ;

PACKER, L .

JOURNAL OF CHROMATOGRAPHY, 1987, 385 :109-117

[23]

Littarru GP, 2004, METHOD ENZYMOL, V378, P170

[24] Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations [J].

Lopez, Luis Carlos ;

Schuelke, Markus ;

Quinzii, Catarina M. ;

Kanki, Tomotake ;

Rodenburg, Richard J. T. ;

Naini, Ali ;

DiMauro, Salvatore ;

Hirano, Michio .

AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 79 (06) :1125-1129

[25] Simultaneous detection of Ubiquinol-10, ubiquinone-10, and tocopherols in human plasma microsamples and macrosamples as a marker of oxidative damage in neonates and infants [J].

Menke, T ;

Niklowitz, P ;

Adam, S ;

Weber, M ;

Schlüter, B ;

Andler, W .

ANALYTICAL BIOCHEMISTRY, 2000, 282 (02) :209-217

[26] Comparison of coenzyme Q10 plasma levels in obese and normal weight children [J].

Menke, T ;

Niklowitz, P ;

de Sousa, G ;

Reinehr, T ;

Andler, W .

CLINICA CHIMICA ACTA, 2004, 349 (1-2) :121-127

[27] Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults [J].

Miles, MV ;

Horn, PS ;

Tang, PH ;

Morrison, JA ;

Miles, L ;

DeGrauw, T ;

Pesce, AJ .

CLINICA CHIMICA ACTA, 2004, 347 (1-2) :139-144

[28] Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans [J].

Miyadera, H ;

Amino, H ;

Hiraishi, A ;

Taka, H ;

Murayama, K ;

Miyoshi, H ;

Sakamoto, K ;

Ishii, N ;

Hekimi, S ;

Kita, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) :7713-7716

[29] Assay of coenzyme Q10 in plasma by a single dilution step [J].

Mosca, F ;

Fattorini, D ;

Bompadre, S ;

Littarru, GP .

ANALYTICAL BIOCHEMISTRY, 2002, 305 (01) :49-54

[30] Familial cerebellar ataxia with muscle coenzyme Q10 deficiency [J].

Musumeci, O ;

Naini, A ;

Slonim, AE ;

Skavin, N ;

Hadjigeorgiou, GL ;

Krawiecki, N ;

Weissman, BM ;

Tsao, CY ;

Mendell, JR ;

Shanske, S ;

De Vivo, DC ;

Hirano, M ;

DiMauro, S .

NEUROLOGY, 2001, 56 (07) :849-855

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