Analysis of coenzyme Q in human blood and tissues

被引：47

作者：

Barshop, Bruce A. ^{[1
]}

Gangoiti, Jon A. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

来源：

MITOCHONDRION | 2007年 / 7卷

关键词：

coenzyme Q(10); electrochemical detection; tandem mass spectrometry; chromatography;

D O I：

10.1016/j.mito.2007.04.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The major coenzyme Q species in humans is the decaprenyl quinoid derivative coenzyme Q(10) (CoQ(10)), and its measurement is somewhat challenging owing to its hydrophobicity and tendency to be oxidized. There are three major methods which are suited for analysis of CoQ(10): HPLC-coupled UV or electrochemical detection, and tandem mass spectrometry. The techniques are discussed, and results of these applications to determine CoQ(10) concentrations in various human fluids and tissues are summarized. (c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：S89 / S93

页数：5

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