Mouse models for breast cancer metastasis

被引：64

作者：

Kim, Ik Soo ^{[1
]}

Baek, Sung Hee ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Biol Sci, Creat Res Initiat Ctr Chromatin Dynam, Seoul 151742, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 394卷 / 03期

关键词：

Mouse model; Metastasis; Breast cancer; Imaging; MAMMARY TUMORIGENESIS; GENE-EXPRESSION; CELL-LINES; TUMORS; MICE; NEU; INTRAVASATION; DISSEMINATION; INVOLVEMENT;

D O I：

10.1016/j.bbrc.2010.03.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis of cancer cells is the main cause of death in most breast cancer patients Although markers for early diagnosis and drugs that limit the spread of cancer to other organs have been developed, it is difficult to prevent the relapse of breast cancer Recent research has highlighted the importance of tumor environment in which communication between tumor cells and the body system occurs Emerging data have suggested that animal models are a good system to investigate this communication Therefore, studies with mouse models have been developed as a reasonable method for a systemic approach to understand breast cancer metastasis In this review, we summarize mouse models of breast cancer and their applications to the study of human breast cancers, and discuss limitation of model system and advanced techniques to overcome it. (C) 2010 Elsevier Inc All rights reserved.

引用

页码：443 / 447

页数：5

共 55 条

[31] Somatic mutation of p53 leads to estrogen receptor α-positive and -negative mouse mammary tumors with high frequency of metastasis [J].

Lin, SCJ ;

Lee, KF ;

Nikitin, AY ;

Hilsenbeck, SG ;

Cardiff, RD ;

Li, AH ;

Kang, KW ;

Frank, SA ;

Lee, WH ;

Lee, EYHP .

CANCER RESEARCH, 2004, 64 (10) :3525-3532

[32] CD44 attenuates metastatic invasion during breast cancer progression [J].

Lopez, JI ;

Camenisch, TD ;

Stevens, MV ;

Sands, BJ ;

McDonald, J ;

Schroeder, JA .

CANCER RESEARCH, 2005, 65 (15) :6755-6763

[33] ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis [J].

Lu, Xin ;

Wang, Qiongqing ;

Hu, Guohong ;

Van Poznak, Catherine ;

Fleisher, Martin ;

Reiss, Michael ;

Massague, Joan ;

Kang, Yibin .

GENES & DEVELOPMENT, 2009, 23 (16) :1882-1894

[34]

Maglione JE, 2001, CANCER RES, V61, P8298

[35] Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/Neu and MMTV-polyoma middle T transgenic mice [J].

Maroulakou, Ioanna G. ;

Oemler, William ;

Naber, Stephen P. ;

Tsichlis, Philip N. .

CANCER RESEARCH, 2007, 67 (01) :167-177

[36] Genes that mediate breast cancer metastasis to lung [J].

Minn, AJ ;

Gupta, GP ;

Siegel, PM ;

Bos, PD ;

Shu, WP ;

Giri, DD ;

Viale, A ;

Olshen, AB ;

Gerald, WL ;

Massagué, J .

NATURE, 2005, 436 (7050) :518-524

[37] Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis [J].

Moody, SE ;

Sarkisian, CJ ;

Hahn, KT ;

Gunther, EJ ;

Pickup, S ;

Dugan, KD ;

Innocent, N ;

Cardiff, RD ;

Schnall, MD ;

Chodosh, LA .

CANCER CELL, 2002, 2 (06) :451-461

[38] Involvement of chemokine receptors in breast cancer metastasis [J].

Müller, A ;

Homey, B ;

Soto, H ;

Ge, NF ;

Catron, D ;

Buchanan, ME ;

McClanahan, T ;

Murphy, E ;

Yuan, W ;

Wagner, SN ;

Barrera, JL ;

Mohar, A ;

Verástegui, E ;

Zlotnik, A .

NATURE, 2001, 410 (6824) :50-56

[39] A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes [J].

Neve, Richard M. ;

Chin, Koei ;

Fridlyand, Jane ;

Yeh, Jennifer ;

Baehner, Frederick L. ;

Fevr, Tea ;

Clark, Laura ;

Bayani, Nora ;

Coppe, Jean-Philippe ;

Tong, Frances ;

Speed, Terry ;

Spellman, Paul T. ;

DeVries, Sandy ;

Lapuk, Anna ;

Wang, Nick J. ;

Kuo, Wen-Lin ;

Stilwell, Jackie L. ;

Pinkel, Daniel ;

Albertson, Donna G. ;

Waldman, Frederic M. ;

McCormick, Frank ;

Dickson, Robert B. ;

Johnson, Michael D. ;

Lippman, Marc ;

Ethier, Stephen ;

Gazdar, Adi ;

Gray, Joe W. .

CANCER CELL, 2006, 10 (06) :515-527

[40] Metastasis: from dissemination to organ-specific colonization [J].

Nguyen, Don X. ;

Bos, Paula D. ;

Massague, Joan .

NATURE REVIEWS CANCER, 2009, 9 (04) :274-U65

← 1 2 3 4 5 6 →