Mouse models for breast cancer metastasis

被引：64

作者：

Kim, Ik Soo ^{[1
]}

Baek, Sung Hee ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Biol Sci, Creat Res Initiat Ctr Chromatin Dynam, Seoul 151742, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 394卷 / 03期

关键词：

Mouse model; Metastasis; Breast cancer; Imaging; MAMMARY TUMORIGENESIS; GENE-EXPRESSION; CELL-LINES; TUMORS; MICE; NEU; INTRAVASATION; DISSEMINATION; INVOLVEMENT;

D O I：

10.1016/j.bbrc.2010.03.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis of cancer cells is the main cause of death in most breast cancer patients Although markers for early diagnosis and drugs that limit the spread of cancer to other organs have been developed, it is difficult to prevent the relapse of breast cancer Recent research has highlighted the importance of tumor environment in which communication between tumor cells and the body system occurs Emerging data have suggested that animal models are a good system to investigate this communication Therefore, studies with mouse models have been developed as a reasonable method for a systemic approach to understand breast cancer metastasis In this review, we summarize mouse models of breast cancer and their applications to the study of human breast cancers, and discuss limitation of model system and advanced techniques to overcome it. (C) 2010 Elsevier Inc All rights reserved.

引用

页码：443 / 447

页数：5

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