Efficient synthesis and resolution of pyrrolizidines

被引：43
作者：
de Figueiredo, Renata Marcia
Froehlich, Roland
Christmann, Mathias
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
[2] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 16期
关键词：
antitumor agents; chiral resolution; lactonization; natural products; organocatalysis;
D O I：
10.1002/anie.200605035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In only two steps the commercially available maleimide 1 is converted into the key pyrrolizidine carboxylic acid unit (2) of the telomerase inhibitor UCS1025A. A kinetic resolution through an enantioselective oxa-Michael lactonization and trituration of the resulting scalemic mixture allow for a virtually quantitative separation of a racemate into the enantiomers. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2883 / 2886
页数：4
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