Lower cognitive function in patients with age-related macular degeneration: a meta-analysis

被引:14
作者
Zhou, Li-Xiao [1 ]
Sun, Cheng-Lin [1 ]
Wei, Li-Juan [1 ]
Gu, Zhi-Min [1 ]
Lv, Liang [1 ]
Dang, Yalong [2 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 5, Dept Ophthalmol, Kangfuqianjie St, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Kangfuqianjie St, Zhengzhou 450001, Peoples R China
关键词
age-related macular degeneration; cognitive impairment; meta-analysis; mini mental state examination; MENTAL-STATE-EXAMINATION; AMYLOID-BETA; PRIMARY-CARE; IMPAIRMENT; DISEASE; DEMENTIA; DRUSEN;
D O I
10.2147/CIA.S102213
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: To investigate the cognitive impairment in patients with age-related macular degeneration (AMD). Methods: Relevant articles were identified through a search of the following electronic databases through October 2015, without language restriction: 1) PubMed; 2) the Cochrane Library; 3) EMBASE; 4) ScienceDirect. Meta-analysis was conducted using STATA 12.0 software. Standardized mean differences with corresponding 95% confidence intervals were calculated. All of the included studies met the following four criteria: 1) the study design was a case-control or randomized controlled trial (RCT) study; 2) the study investigated cognitive function in the patient with AMD; 3) the diagnoses of AMD must be provided; 4) there were sufficient scores data to extract for evaluating cognitive function between cases and controls. The Newcastle-Ottawa Scale criteria were used to assess the methodological quality of the studies. Results: Of the initial 278 literatures, only six case-control and one RCT studies met all of the inclusion criteria. A total of 794 AMD patients and 1,227 controls were included in this study. Five studies were performed with mini-mental state examination (MMSE), two studies with animal fluency, two studies with trail making test (TMT)-A and -B, one study with Mini-Cog. Results of the meta-analysis revealed lower cognitive function test scores in patients with AMD, especially with MMSE and Mini-Cog test (P <= 0.001 for all). The results also showed that differences in the TMT-A (except AMD [total] vs controls) and TMT-B test had no statistical significance (P>0.01). The Newcastle-Ottawa Scale score was >= 5 for all of the included studies. Based on the sensitivity analysis, no single study influenced the overall pooled estimates. Conclusion: This meta-analysis suggests lower cognitive function test scores in patients with AMD, especially with MMSE and Mini-Cog test. The other cognitive impairment screening tests, such as animal fluency test and TMT, need more studies to assess.
引用
收藏
页码:215 / 223
页数:9
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