ASK1 signalling regulates brown and beige adipocyte function

被引：60

作者：

Hattori, Kazuki ^{[1
]}

Naguro, Isao ^{[1
]}

Okabe, Kohki ^{[2
,3
]}

Funatsu, Takashi ^{[2
]}

Furutani, Shotaro ^{[1
]}

Takeda, Kohsuke ^{[4
]}

Ichijo, Hidenori ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Cell Signaling, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Bioanalyt Chem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[3] JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

[4] Nagasaki Univ, Grad Sch Biomed Sci, Div Cell Regulat, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

日本学术振兴会;

关键词：

WHITE ADIPOSE-TISSUE; PROTEIN-KINASE; ADULT HUMANS; INDUCED THERMOGENESIS; INSULIN-RESISTANCE; FAMILY PROTEINS; MAP KINASE; FAT-CELLS; ACTIVATION; APOPTOSIS;

D O I：

10.1038/ncomms11158

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function.

引用

页数：10

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