The genome of a songbird

被引：630

作者：

Warren, Wesley C. ^{[1
]}

Clayton, David F. ^{[2
]}

Ellegren, Hans ^{[3
]}

Arnold, Arthur P. ^{[4
]}

Hillier, LaDeana W. ^{[1
]}

Kuenstner, Axel ^{[3
]}

Searle, Steve ^{[5
]}

White, Simon ^{[5
]}

Vilella, Albert J. ^{[6
]}

Fairley, Susan ^{[5
]}

Heger, Andreas ^{[7
]}

Kong, Lesheng ^{[7
]}

Ponting, Chris P. ^{[7
]}

Jarvis, Erich D. ^{[8
]}

Mello, Claudio V. ^{[9
]}

Minx, Pat ^{[1
]}

Lovell, Peter ^{[9
]}

Velho, Tarciso A. F. ^{[9
]}

Ferris, Margaret ^{[2
]}

Balakrishnan, Christopher N. ^{[2
]}

Sinha, Saurabh ^{[2
]}

Blatti, Charles ^{[2
]}

London, Sarah E. ^{[2
]}

Li, Yun ^{[2
]}

Lin, Ya-Chi ^{[2
]}

George, Julia ^{[2
]}

Sweedler, Jonathan ^{[2
]}

Southey, Bruce ^{[2
]}

Gunaratne, Preethi ^{[10
]}

Watson, Michael ^{[11
]}

Nam, Kiwoong ^{[3
]}

Backstroem, Niclas ^{[3
]}

Smeds, Linnea ^{[3
]}

Nabholz, Benoit ^{[3
]}

Itoh, Yuichiro ^{[4
]}

Whitney, Osceola ^{[8
]}

Pfenning, Andreas R. ^{[8
]}

Howard, Jason ^{[8
]}

Voelker, Martin ^{[11
]}

Skinner, Bejamin M. ^{[12
]}

Griffin, Darren K. ^{[12
]}

Ye, Liang ^{[1
]}

McLaren, William M. ^{[6
]}

Flicek, Paul ^{[9
]}

Quesada, Victor ^{[13
]}

Velasco, Gloria ^{[13
]}

Lopez-Otin, Carlos ^{[13
]}

Puente, Xose S. ^{[13
]}

Olender, Tsviya ^{[14
]}

Lancet, Doron ^{[14
]}

机构：

[1] Washington Univ, Genome Ctr, Sch Med, St Louis, MO 63108 USA

[2] Univ Illinois, Urbana, IL 61801 USA

[3] Uppsala Univ, Inst Evolut & Genet Syst, S-75236 Uppsala, Sweden

[4] Univ Calif Los Angeles, Los Angeles, CA 90056 USA

[5] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[6] EMBL EBI, Cambridge CB10 1SD, England

[7] Univ Oxford, Funct Genom Unit, MRC, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

[8] Duke Univ, Med Ctr, Dept Neurobiol, Howard Hughes Med Inst, Durham, NC 27710 USA

[9] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA

[10] Univ Houston, Dept Biol & Biochem, Houston, TX 77204 USA

[11] Inst Anim Hlth, Dept Bioinformat, Compton RG20 7NN, Berks, England

[12] Univ Kent, Dept Biosci, Canterbury CT2 7NJ, Kent, England

[13] Univ Oviedo, Dept Bioquim & Biol Mol, Inst Univ Oncol, E-33006 Oviedo, Spain

[14] Weizmann Inst Sci, Dept Mol Genet, Crown Human Genome Ctr, IL-76100 Rehovot, Israel

[15] Inst Syst Biol, Seattle, WA 98103 USA

[16] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA

[17] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Genet, Aurora, CO 80045 USA

[18] Univ Washington, Seattle, WA 98195 USA

[19] Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England

[20] Free Univ Berlin, Inst Biol, D-14195 Berlin, Germany

[21] Univ Edinburgh, Roslin Inst, Edinburgh EH25 9OS, Midlothian, Scotland

[22] Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh EH25 9OS, Midlothian, Scotland

[23] Max Planck Inst Mol Genet, Dept Vertebrate Genom, D-14195 Berlin, Germany

[24] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA

[25] Monsanto Co, St Louis, MO 63167 USA

[26] Louisiana State Univ, Hlth Sci Ctr, Ctr Neurosci, New Orleans, LA 70112 USA

来源：

NATURE | 2010年 / 464卷 / 7289期

基金：

英国生物技术与生命科学研究理事会; 瑞典研究理事会;

关键词：

GENE-EXPRESSION; DOSAGE COMPENSATION; LEARNED BIRDSONG; BRAIN; EVOLUTION; NUCLEUS; CHICKEN; MECHANISMS; REVEALS; RNA;

D O I：

10.1038/nature08819

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The zebra finch is an important model organism in several fields(1,2) with unique relevance to human neuroscience(3,4). Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented only in humans and a few other animals and lacking in the chicken(5)-the only bird with a sequenced genome until now(6). Here we present a structural, functional and comparative analysis of the genome sequence of the zebra finch (Taeniopygia guttata), which is a songbird belonging to the large avian order Passeriformes(7). We find that the overall structures of the genomes are similar in zebra finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene family expansions, the number of long-terminal-repeat-based retrotransposons, and mechanisms of sex chromosome dosage compensation. We show that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets. We also show evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience. These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour.

引用

页码：757 / 762

页数：6

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