Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice

被引：60
作者：
Fragoso, G
Lamoyi, E
Mellor, A
Lomelí, C
Hernández, M
Sciutto, E
机构：
[1] Natl Autonomous Univ Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico
[2] Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA
来源：
INFECTION AND IMMUNITY | 1998年 / 66卷 / 02期
关键词：
D O I：
10.1128/IAI.66.2.760-764.1998
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps, whereas BALB/cJ expresses Qa-2 and is highly resistant, In this study, we investigated the role of Qa-2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN x (C57BL/6J x BALB/cAnN)F-1, and BALB/cAnN x (BALB/cJ x BALB/cAnN)F-1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.
引用
收藏
页码：760 / 764
页数：5
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