Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice

被引：60

作者：

Fragoso, G

Lamoyi, E

Mellor, A

Lomelí, C

Hernández, M

Sciutto, E

机构：

[1] Natl Autonomous Univ Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico

[2] Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 02期

关键词：

D O I：

10.1128/IAI.66.2.760-764.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps, whereas BALB/cJ expresses Qa-2 and is highly resistant, In this study, we investigated the role of Qa-2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN x (C57BL/6J x BALB/cAnN)F-1, and BALB/cAnN x (BALB/cJ x BALB/cAnN)F-1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.

引用

页码：760 / 764

页数：5

共 29 条

[1]

ALUJA A, 1982, CYSTICERCOSIS PRESEN, P53

[2] Genetic control of susceptibility to Taenia crassiceps cysticercosis [J].