Visceral afferents - Determinants and modulation of excitability

被引：22

作者：

Beyak, Michael J. ^{[1
]}

机构：

[1] Queens Univ, GIDRU, Kingston, ON K7L 2V7, Canada

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2010年 / 153卷 / 1-2期

关键词：

Visceral afferent; Ion channels; Pharmacology; Excitability; GLUCAGON-LIKE PEPTIDE-1; ROOT GANGLION NEURONS; RECEPTORS INHIBIT MECHANOSENSITIVITY; INTRAGANGLIONIC LAMINAR ENDINGS; SENSITIVE SODIUM CURRENTS; COLON SENSORY NEURONS; ALPHA-GENE EXPRESSION; RAT URINARY-BLADDER; BRAIN-GUT AXIS; HYDROGEN-SULFIDE;

D O I：

10.1016/j.autneu.2009.07.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An essential property of visceral sensory afferents is to be able to alter their firing properties in response to changes in the microenvironment at the level of the sensory ending. Significant progress has been made in recent years in understanding the ionic mechanisms of the regulation of afferent neuronal excitability, and in identifying the mechanisms by which this can be altered. This article will review some of the recent developments in the state of knowledge regarding mechanisms of increased excitability after inflammation, and pharmacological modulation of excitability, concentrating on afferent nerves innervating the GI tract and urinary bladder. (C) 2009 Elsevier B.V. All rights reserved.

引用

收藏

页码：69 / 78

页数：10

相关论文

共 105 条

[31] Bladder afferent sensitivity in wild-type and TRPV1 knockout mice [J].

Daly, D. ;

Rong, W. ;

Chess-Williams, R. ;

Chapple, C. ;

Grundy, D. .

JOURNAL OF PHYSIOLOGY-LONDON, 2007, 583 (02) :663-674

[32] Gastric ulcers evoke hyperexcitability and enhance P2X receptor function in rat gastric sensory neurons [J].

Dang, K ;

Bielfeldt, K ;

Lamb, K ;

Gebhart, GF .

JOURNAL OF NEUROPHYSIOLOGY, 2005, 93 (06) :3112-3119

[33] Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons [J].

Dang, K ;

Bielefeldt, K ;

Gebhart, GF .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2004, 286 (04) :G573-G579

[34] Cyclophosphamide-induced bladder inflammation sensitizes and enhances P2X receptor function in rat bladder sensory neurons [J].

Dang, Khoa ;

Lamb, Kenneth ;

Cohen, Michael ;

Bielefeldt, Klaus ;

Gebhart, G. F. .

JOURNAL OF NEUROPHYSIOLOGY, 2008, 99 (01) :49-59

[35] The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats [J].

Date, Y ;

Murakami, N ;

Toshinai, K ;

Matsukura, S ;

Niijima, A ;

Matsuo, H ;

Kangawa, K ;

Nakazato, M .

GASTROENTEROLOGY, 2002, 123 (04) :1120-1128

[36] TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats [J].

De Schepper, H. U. ;

De Winter, B. Y. ;

Van Nassauw, L. ;

Timmermans, J. -P. ;

Herman, A. G. ;

Pelckmans, P. A. ;

De Man, J. G. .

JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (21) :5247-5258

[37] Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels [J].

Distrutti, E ;

Sediari, L ;

Mencarelli, A ;

Renga, B ;

Orlandi, S ;

Antonelli, E ;

Roviezzo, F ;

Morelli, A ;

Cirino, G ;

Wallace, JL ;

Fiorucci, S .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 316 (01) :325-335

[38] Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression [J].

Fang, Xin ;

Djouhri, Laiche ;

McMullan, Simon ;

Berry, Carol ;

Waxman, Stephen G. ;

Okuse, Kenji ;

Lawson, Sally N. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (27) :7281-7292

[39]

Gaisano G, 2007, GASTROENTEROLOGY, V132, pA36

[40] The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum [J].

Gallego, D. ;

Clave, P. ;

Donovan, J. ;

Rahmati, R. ;

Grundy, D. ;

Jimenez, M. ;

Beyak, M. J. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2008, 20 (12) :1306-1316

← 1 2 3 4 5 6 7 8 9 10 →