Visceral afferents - Determinants and modulation of excitability

被引：22

作者：

Beyak, Michael J. ^{[1
]}

机构：

[1] Queens Univ, GIDRU, Kingston, ON K7L 2V7, Canada

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2010年 / 153卷 / 1-2期

关键词：

Visceral afferent; Ion channels; Pharmacology; Excitability; GLUCAGON-LIKE PEPTIDE-1; ROOT GANGLION NEURONS; RECEPTORS INHIBIT MECHANOSENSITIVITY; INTRAGANGLIONIC LAMINAR ENDINGS; SENSITIVE SODIUM CURRENTS; COLON SENSORY NEURONS; ALPHA-GENE EXPRESSION; RAT URINARY-BLADDER; BRAIN-GUT AXIS; HYDROGEN-SULFIDE;

D O I：

10.1016/j.autneu.2009.07.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An essential property of visceral sensory afferents is to be able to alter their firing properties in response to changes in the microenvironment at the level of the sensory ending. Significant progress has been made in recent years in understanding the ionic mechanisms of the regulation of afferent neuronal excitability, and in identifying the mechanisms by which this can be altered. This article will review some of the recent developments in the state of knowledge regarding mechanisms of increased excitability after inflammation, and pharmacological modulation of excitability, concentrating on afferent nerves innervating the GI tract and urinary bladder. (C) 2009 Elsevier B.V. All rights reserved.

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页码：69 / 78

页数：10

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