Efficient Synthesis and Spectroscopy of 3,3-Dimethyl-2,3,4,5,10,11-hexahydro-8-[(o-; and p-methyl)phenoxy]-11-[(o-; and p-substituted)phenyl]-1H-dibenzo-[b,e][1,4]diazepin-1-ones

被引：4

作者：

Cortes Cortes, Eduardo ^{[1
]}

Andrade Meneses, Ociel E. ^{[2
]}

Garcia-Mellado, Olivia ^{[2
]}

Collera Zuniga, Ofelia ^{[1
]}

Brosla Naranjo-Rodriguez, Elia ^{[3
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Dept Sintesis Organ, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Estudios Super Cuatitlan, Dept Ciencias Quim, Izcalli 54740, Estado Mexico, Mexico

[3] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 06期

关键词：

SPECTRAL PROPERTIES; DERIVATIVES;

D O I：

10.1002/jhet.159

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An easy synthesis of four steps to afforded 12 new derivatives of 3.3-dimethyl-2,3,4,5,10,11-hexahydro-8-[(o-; and p-methyl)phenoxy]-11-[(o-; and p-substituted)phenyl]-1H-dibenzo-[b,e][1,4]diazep-in-1-ones IV, 1-12 with potential biological and pharmacological activity as sedative, hypnotic-muscular relaxing, anticonvulsant, and schizophrenia treatment of the central nervous system (CNS). The final products have been obtained with good yields, by condensation and cyclization between 3-(4-[(o-; and p-methyl)phenoxy]-1,2-phenylendiamine)-5,5-dimethyl-2-cyclohexanone III, with the corresponding (o-; and p-R)benzaldehyde. The structure of all derivatives was corroborated by spectroscopy of ir, H-1, and C-13 NMR, with bi-dimensional experiments and EI-MS in low and high resolution with collision-induced dissociation experiments (CID).

引用

页码：1113 / 1118

页数：6

共 6 条

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