Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport

被引：57

作者：

Goody, Roger Sidney ^{[1
]}

Mueller, Matthias Philipp ^{[1
]}

Wu, Yao-Wen ^{[2
]}

机构：

[1] Max Planck Inst Mol Physiol, Dept Struct Biochem, Otto Hahn Str 11, D-44227 Dortmund, Germany

[2] Max Planck Gesell, Chem Genom Ctr, D-44227 Dortmund, Germany

来源：

BIOLOGICAL CHEMISTRY | 2017年 / 398卷 / 5-6期

关键词：

effectors; GAPs; GEFs; GTPases; Legionella; Rabs; targeting; GDP-DISSOCIATION INHIBITOR; C-TERMINAL DOMAIN; SMALL GTPASE RAB1; NUCLEOTIDE EXCHANGE; PHOSPHATIDYLINOSITOL; 4-PHOSPHATE; POSTTRANSLATIONAL MODIFICATIONS; EFFECTOR PROTEIN; STRUCTURAL BASIS; LEGIONELLA; COMPLEX;

D O I：

10.1515/hsz-2016-0274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our understanding of the manner in which Rab proteins regulate intracellular vesicular transport has progressed remarkably in the last one or two decades by application of a wide spectrum of biochemical, biophysical and cell biological methods, augmented by the methods of chemical biology. Important additional insights have arisen from examination of the manner in which certain bacteria can manipulate vesicular transport mechanisms. The progress in these areas is summarized here.

引用

页码：565 / 575

页数：11

共 55 条

[1] TIP47 is a key effector for Rab9 localization [J].

Aivazian, Dikran ;

Serrano, Ramon L. ;

Pfeffer, Suzanne .

JOURNAL OF CELL BIOLOGY, 2006, 173 (06) :917-926

[2] Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro [J].

Alexandrov, K ;

Heinemann, I ;

Durek, T ;

Sidorovitch, V ;

Goody, RS ;

Waldmann, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (20) :5648-5649

[3] Multiple regions contribute to membrane targeting of Rab GTPases [J].

Ali, BR ;

Wasmeier, C ;

Lamoreux, L ;

Strom, M ;

Seabra, MC .

JOURNAL OF CELL SCIENCE, 2004, 117 (26) :6401-6412

[4] RabGEFs are a major determinant for specific Rab membrane targeting [J].

Bluemer, Julia ;

Rey, Juliana ;

Dehmelt, Leif ;

Mazel, Tomas ;

Wu, Yao-Wen ;

Bastiaens, Philippe ;

Goody, Roger S. ;

Itzen, Aymelt .

JOURNAL OF CELL BIOLOGY, 2013, 200 (03) :287-300

[5] Synthesis of functionalized Rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation [J].

Brunsveld, L ;

Watzke, A ;

Durek, T ;

Alexandrov, K ;

Goody, RS ;

Waldmann, H .

CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (09) :2756-2772

[6] HYPERVARIABLE C-TERMINAL DOMAIN OF RAB PROTEINS ACTS AS A TARGETING SIGNAL [J].

CHAVRIER, P ;

GORVEL, JP ;

STELZER, E ;

SIMONS, K ;

GRUENBERG, J ;

ZERIAL, M .

NATURE, 1991, 353 (6346) :769-772

[7] Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State [J].

Cheng, Wei ;

Yin, Kun ;

Lu, Defen ;

Li, Bingqing ;

Zhu, Deyu ;

Chen, Yuzhen ;

Zhang, Hao ;

Xu, Sujuan ;

Chai, Jijie ;

Gu, Lichuan .

PLOS PATHOGENS, 2012, 8 (03)

[8] The Legionella pneumophila LidA protein:: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity [J].

Conover, GM ;

Derré, I ;

Vogel, JP ;

Isberg, RR .

MOLECULAR MICROBIOLOGY, 2003, 48 (02) :305-321

[9] Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI [J].

DiracSvejstrup, AB ;

Sumizawa, T ;

Pfeffer, SR .

EMBO JOURNAL, 1997, 16 (03) :465-472

[10] Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses [J].

Dong, Na ;

Zhu, Yongqun ;

Lu, Qiuhe ;

Hu, Liyan ;

Zheng, Yuqing ;

Shao, Feng .

CELL, 2012, 150 (05) :1029-1041

← 1 2 3 4 5 6 →