Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring

被引：83
作者：
Foroumadi, Alireza
Emami, Saeed
Mansouri, Shahla
Javidnia, Azita
Saeid-Adeli, Nosratollah
Shirazi, Farshad H.
Shafiee, Abbas [1 ]
机构：
[1] Univ Teheran Med Sci, Fac Pharm, Dept Med Chem, Tehran 14174, Iran
[2] Univ Teheran Med Sci, Pharmaceut Sci Res Ctr, Tehran 14174, Iran
[3] Mazandaran Univ Med Sci, Fac Pharm, Dept Med Chem, Sari, Iran
[4] Kerman Univ Med Sci, Fac Med, Dept Microbiol, Kerman, Iran
[5] Shahid Beheshti Univ Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Tehran, Iran
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 07期
基金：
美国国家科学基金会;
关键词：
Quinolones; levofloxacin derivatives; in vitro antibacterial activity; FLUOROQUINOLONES; OFLOXACIN;
D O I：
10.1016/j.ejmech.2006.12.034
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A number of levofloxacin analogues carrying a 2-aryl-2-oxoethyl or a 2-aryl-2-oxyiminoethyl moiety attached to the piperazine ring at C-10 position have been prepared and evaluated as antibacterial agents against a series of Gram-positive and Gram-negative bacteria. Some of them exhibited significant inhibitory activity against Gram-positive bacteria. (c) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：985 / 992
页数：8
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