Metabolic tumor volume and total lesion glycolysis on FDG-PET/CT can predict overall survival after 90Y radioembolization of colorectal liver metastases: A comparison with SUVmax, SUVpeak, and RECIST 1.0

被引:45
作者
Shady, Waleed [1 ]
Kishore, Sirish [3 ,5 ]
Gavane, Somali [3 ]
Do, Richard K. [2 ]
Osborne, Joseph R. [3 ]
Ulaner, Gary A. [3 ]
Gonen, Mithat [4 ]
Ziv, Etay [1 ]
Boas, Franz E. [1 ]
Sofocleous, Constantinos T. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Radiol, Sect Intervent Radiol, 1275 York Ave, New York 10065, NY USA
[2] Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York 10065, NY USA
[3] Mem Sloan Kettering Canc Ctr, Dept Nucl Med, 1275 York Ave, New York 10065, NY USA
[4] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, 1275 York Ave, New York 10065, NY USA
[5] Stanford Univ, Med Ctr, Div Intervent Radiol, 300 Pasteur Dr,Room H3600, Stanford, CA 94305 USA
关键词
Radioembolizat ion; PET/CT; RECIST; 1.0; Colorectal liver metastases; Overall survival; INTERNAL RADIATION-THERAPY; POSITRON-EMISSION-TOMOGRAPHY; HEPATIC METASTASES; RADIOFREQUENCY ABLATION; RESIN MICROSPHERES; PROGNOSTIC VALUE; F-18-FDG PET/CT; COLON-CANCER; RESECTION; RECURRENCE;
D O I
10.1016/j.ejrad.2016.03.029
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To compare the performance of 4 metrics of metabolic response on FDG-PET/CT against RECIST 1.0 for determining response and predicting overall survival (OS) following Y-90 resin microspheres radioembolization of colorectal liver metastases (CLM). Methods: We conducted an IRB-waived retrospective review of our radioembolization database to identify patients with unresectable CLM treated between December 2009 and December 2013. We included patients who had both PET/CT and contrast enhanced CT (CECT) available at baseline and on the first follow-up post-radioembolization. On baseline CECT up to five target tumors were chosen per patient according to RECIST 1.0. Four metrics of FDG-avidity (SUVmax, SUVpeak, metabolic tumor volume (MTV), and total lesion glycolysis (TLG)) on PET/CT were measured for the same target tumors. Using RECIST 1.0, patients were classified as no progression (partial response or stable disease) and progression. For each PET metric, a cut-off point of >30% decrease was chosen to define response. OS was calculated from the time of radioembolization using Kaplan-Meier methodology. The log-rank test was used for univariate analysis to identify predictors of OS. Results: The study enrolled 49 patients with 119 target tumors; a median of 2 (range: 1-5) tumors were selected per patient. Median OS was 12.7 months (95%CI: 7.2-16.7). Response by MTV (P = 0.035) and TLG (P= 0.044) reached statistical significance in predicting OS. Response by SUVmax (P= 0.21), SUVpeak (P = 0.20) or no progression by RECIST 1.0 (P=0.44) did not predict OS. Conclusion: Metabolic response based on changes in MTV and TLG can predict OS post-radioembolization of CLM. (C) 2016 Published by Elsevier Ireland Ltd.
引用
收藏
页码:1224 / 1231
页数:8
相关论文
共 38 条
  • [1] Abdalla EK, 2004, ANN SURG, V239, P818, DOI 10.1097/01.sla.0000128305.90650.71
  • [2] Annunziata S, 2014, SCI WORLD J, V2014, DOI DOI 10.1155/2014/879469
  • [3] [Anonymous], ANN SURG
  • [4] Localized Colon Cancer, Version 3.2013 Featured Updates to the NCCN Guidelines
    Benson, Al B., III
    Bekaii-Saab, Tanios
    Chan, Emily
    Chen, Yi-Jen
    Choti, Michael A.
    Cooper, Harry S.
    Engstrom, Paul F.
    Enzinger, Peter C.
    Fakih, Marwan G.
    Fenton, Moon J.
    Fuchs, Charles S.
    Grem, Jean L.
    Hunt, Steven
    Kamel, Ahmed
    Leong, Lucille A.
    Lin, Edward
    May, Kilian Salerno
    Mulcahy, Mary F.
    Murphy, Kate
    Rohren, Eric
    Ryan, David P.
    Saltz, Leonard
    Sharma, Sunil
    Shibata, David
    Skibber, John M.
    Small, William, Jr.
    Sofocleous, Constantinos T.
    Venook, Alan P.
    Willett, Christopher G.
    Gregory, Kristina M.
    Freedman-Cass, Deborah A.
    [J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2013, 11 (05): : 519 - 528
  • [5] Development of a Research Agenda for the Management of Metastatic Colorectal Cancer: Proceedings from a Multidisciplinary Research Consensus Panel
    d'Othee, Bertrand Janne
    Sofocleous, Constantinos T.
    Hanna, Nader
    Lewandowski, Robert J.
    Soulen, Michael C.
    Vauthey, Jean-Nicolas
    Cohen, Steven J.
    Venook, Alan P.
    Johnson, Matthew S.
    Kennedy, Andrew S.
    Murthy, Ravi
    Geschwind, Jean-Francois
    Kee, Stephen T.
    [J]. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2012, 23 (02) : 153 - 163
  • [6] Rates and Patterns of Recurrence Following Curative Intent Surgery for Colorectal Liver Metastasis An International Multi-Institutional Analysis of 1669 Patients
    de Jong, Mechteld C.
    Pulitano, Carlo
    Ribero, Dario
    Strub, Jennifer
    Mentha, Gilles
    Schulick, Richard D.
    Choti, Michael A.
    Aldrighetti, Luca
    Capussotti, Lorenzo
    Pawlik, Timothy M.
    [J]. ANNALS OF SURGERY, 2009, 250 (03) : 440 - 448
  • [7] Validation of Several SUV-Based Parameters Derived from 18F-FDG PET for Prediction of Survival After SIRT of Hepatic Metastases from Colorectal Cancer
    Fendler, Wolfgang Peter
    Tiega, Donfack Beauclair Philippe
    Ilhan, Harun
    Paprottka, Philipp M.
    Heinemann, Volker
    Jakobs, Tobias F.
    Bartenstein, Peter
    Hacker, Marcus
    Haug, Alexander Robert
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2013, 54 (08) : 1202 - 1208
  • [8] Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer - Analysis of 1001 consecutive cases
    Fong, Y
    Fortner, J
    Sun, RL
    Brennan, MF
    Blumgart, LH
    [J]. ANNALS OF SURGERY, 1999, 230 (03) : 309 - 318
  • [9] Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, the interventional oncology sans frontiSres meeting 2013
    Gillams, Alice
    Goldberg, Nahum
    Ahmed, Muneeb
    Bale, Reto
    Breen, David
    Callstrom, Matthew
    Chen, Min Hua
    Choi, Byung Ihn
    de Baere, Thierry
    Dupuy, Damian
    Gangi, Afshin
    Gervais, Debra
    Helmberger, Thomas
    Jung, Ernst-Michael
    Lee, Fred
    Lencioni, Riccardo
    Liang, Ping
    Livraghi, Tito
    Lu, David
    Meloni, Franca
    Pereira, Philippe
    Piscaglia, Fabio
    Rhim, Hyunchul
    Salem, Riad
    Sofocleous, Constantinos
    Solomon, Stephen B.
    Soulen, Michael
    Tanaka, Masatoshi
    Vogl, Thomas
    Wood, Brad
    Solbiati, Luigi
    [J]. EUROPEAN RADIOLOGY, 2015, 25 (12) : 3438 - 3454
  • [10] The prognostic value of functional tumor volume and total lesion glycolysis in patients with colorectal cancer liver metastases undergoing 90Y selective internal radiation therapy plus chemotherapy
    Gulec, Seza A.
    Suthar, Rekha R.
    Barot, Tushar C.
    Pennington, Kenneth
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2011, 38 (07) : 1289 - 1295