Protein Kinase C/Mitogen-Activated Protein Kinase Signaling in Keratinocyte Differentiation control

被引：9
|
作者：
Denning, Mitchell F. [1 ,2 ]
机构：
[1] Loyola Univ, Skin Canc Res Program, Dept Pathol, Maywood, IL 60153 USA
[2] Loyola Univ, Skin Canc Res Program, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2010年 / 130卷 / 08期
关键词：
INVOLUCRIN GENE; C-DELTA; FILAGGRIN;
D O I：
10.1038/jid.2010.194
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Proper epidermal keratinocyte differentiation, which is necessary for cutaneous barrier function, is altered in many common skin diseases. Keratinocyte differentiation is controlled by a complex signaling network involving multiple members of the protein kinase c and mitogen-activated protein kinase signaling kinases. Using an RNA interference knockdown approach, Adhikary et al. identified essential nodes in this signaling network, revealing remarkable kinase specificity.
引用
收藏
页码：1968 / 1970
页数：4
相关论文
共 27 条
  • [1] Inactivation of mitogen-activated protein kinase signaling pathway reduces caspase-14 expression in impaired keratinocytes
    Dang, Ningning
    Pang, Shuguang
    Song, Haiyan
    An, Liguo
    Ma, Xiaoli
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2016, 19 (01) : 28 - 33
  • [2] p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis
    Efimova, Tatiana
    CELL CYCLE, 2010, 9 (03) : 498 - 505
  • [3] Differential Expression of Mitogen-Activated Protein Kinase Signaling Pathways in the Human Choroid-Retinal Pigment Epithelial Complex Indicates Regional Predisposition to Disease
    Hailey, Dylan R.
    Kanjilal, Debolina
    Koulen, Peter
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (18)
  • [4] Korean red ginseng water extract alleviates atopic dermatitis-like inflammatory responses by negative regulation of mitogen-activated protein kinase signaling pathway in vivo
    Park, Ju-Hyoung
    Ahn, Eun-Kyung
    Ko, Hye-Jin
    Lee, Jae Yeon
    Hwang, Seung-Mi
    Ko, SeonMi
    Oh, Joa Sub
    BIOMEDICINE & PHARMACOTHERAPY, 2019, 117
  • [5] Differentiation of cultured human epidermal keratinocytes at high cell densities is mediated by endogenous activation of the protein kinase C signaling pathway
    Lee, YS
    Yuspa, SH
    Dlugosz, AA
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 111 (05) : 762 - 766
  • [6] METABOTROPIC GLUTAMATE RECEPTOR 5 PROMOTES PROLIFERATION OF HUMAN NEURAL STEM/PROGENITOR CELLS WITH ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASES SIGNALING PATHWAY IN VITRO
    Zhao, L.
    Jiao, Q.
    Yang, P.
    Chen, X.
    Zhang, J.
    Zhao, B.
    Zheng, P.
    Liu, Y.
    NEUROSCIENCE, 2011, 192 : 185 - 194
  • [7] It Takes Two to Tango: Activation of Protein Kinase D by Dimerization
    Reinhardt, Ronja
    Truebestein, Linda
    Schmidt, Heiko A.
    Leonard, Thomas A.
    BIOESSAYS, 2020, 42 (04)
  • [8] Inhibiting Tyrosine Phosphorylation of Protein Kinase Cδ( PKCδ) Protects the Salivary Gland from Radiation Damage
    Wie, Sten M.
    Adwan, Tariq S.
    DeGregori, James
    Anderson, Steven M.
    Reyland, Mary E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (15) : 10900 - 10908
  • [9] A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-κB activities
    Chen, Jun
    Giridhary, Karthik V.
    Zhang, Liyong
    Xu, Shuping
    Wang, Q. Jane
    CARCINOGENESIS, 2011, 32 (08) : 1198 - 1206
  • [10] Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells
    Chen, Min-Bin
    Wu, Xiao-Yang
    Gu, Jin-Hua
    Guo, Qing-Tao
    Shen, Wen-Xiang
    Lu, Pei-Hua
    CELL BIOCHEMISTRY AND BIOPHYSICS, 2011, 60 (03) : 311 - 322
123