From Bench to Booth: Examining Hair-Cell Regeneration Through an Audiologist's Scope

被引：2

作者：

Lewis, Rebecca M. ^{[1
,2
]}

机构：

[1] Whisper Ai, Dept Clin Res, San Francisco, CA 94110 USA

[2] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY | 2021年 / 32卷 / 10期

关键词：

hearing; auditory; cochlear implants; STARLING STURNUS-VULGARIS; CHICK BASILAR PAPILLA; INNER-EAR; ACOUSTIC TRAUMA; OTOACOUSTIC EMISSIONS; THRESHOLD SHIFT; PLACE PRINCIPLE; RECOVERY; HEARING; EXPRESSION;

D O I：

10.1055/s-0041-1731700

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Damage to auditory hair cells is a key feature of sensorineural hearing loss due to aging, noise exposure, or ototoxic drugs. Though hair-cell loss is permanent in humans, research in bird species led to the discovery that analogous hair cells of the avian basilar papilla are able to regenerate after being damaged by ototoxic agents. Regeneration appears to occur through a combination of the mitotic expansion of a precursor population of supporting cells and direct transdifferentiation of supporting cells into functioning hair cells. This review will synthesize the relevant anatomy and pathophysiology of sensorineural hearing loss, the historical observations that led to the genesis of the hair-cell regeneration field, and perspectives on initial human hair-cell regeneration trials.

引用

页码：654 / 660

页数：7

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