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Fluorescence-guided surgery for high-grade gliomas
被引:61
|作者:
Lakomkin, Nikita
[1
,2
]
Hadjipanayis, Constantinos G.
[1
,2
]
机构:
[1] Mt Sinai Hlth Syst, Icahn Sch Med Mt Sinai, Dept Neurosurg, New York, NY USA
[2] Mt Sinai Hlth Syst, Mt Sinai Beth Israel, Icahn Sch Med, Dept Neurosurg, New York, NY USA
关键词:
5-aminolevulinic acid (5-ALA);
glioblastoma multiforme (GBM);
photodynamic therapy;
INDUCED PROTOPORPHYRIN-IX;
INTERSTITIAL PHOTODYNAMIC THERAPY;
COMBINING 5-AMINOLEVULINIC ACID;
MALIGNANT BRAIN-TUMORS;
OF-THE-LITERATURE;
GLIOBLASTOMA-MULTIFORME;
INTRAOPERATIVE FLUORESCENCE;
PHASE-II;
IN-VITRO;
RESECTION;
D O I:
10.1002/jso.25154
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
5-aminolevulinic acid (5-ALA) is a prodrug that results in the fluorescence of high-grade gliomas relative to the surrounding brain parenchyma. 5-ALA has been increasingly utilized in fluorescence-guided surgery for these tumors, and its intraoperative use has been associated with a significantly improved extent of resection and progression-free survival. This review outlines the growing body of evidence that has culminated in the recent Food and Drug Administration approval of 5-ALA, as well as emerging applications for this agent.
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页码:356 / 361
页数:6
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