Plasma progesterone levels and cocaine-seeking in freely cycling female rats across the estrous cycle

被引:114
作者
Feltenstein, Matthew W. [1 ]
See, Ronald E. [1 ]
机构
[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
关键词
progesterone; female; estrous cycle; cocaine; self-administration; reinstatement;
D O I
10.1016/j.drugalcdep.2006.12.017
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Previous studies have reported sex and estrous cycle-dependent differences in the reinstatement of cocaine-seeking triggered by cocaine injections or drug-paired cues. However, the relationship between estradiol or progesterone levels and cocaine-seeking in a reinstatement model of relapse has not been explored. Thus, we examined changes in plasma hormone levels during cocaine-taking and -seeking behaviors in gonadally intact female rats. Rats self-administered cocaine (0.5 mg/kg infusion) during daily 2-h sessions, followed by extinction. For reinstatement, cocaine (0, 5, or 10 mg/kg, i.p.) was administered 30 min prior to testing. Vaginal smears and blood samples were collected prior to and during chronic cocaine self-administration, extinction, and reinstatement testing. Relative to non-estrous females, females in estrus showed greater responding during self-administration, extinction, and during cocaine-primed reinstatement. The highest progesterone levels were noted at the time of lowest cocaine-seeking (proestrus) and the lowest levels of progesterone occurred at the time of highest cocaine-seeking (estrus). In contrast, plasma estradiol levels did not show any clear pattern with cocaine-seeking. These data from an animal model of relapse supports recent clinical evidence that progesterone reduces subjective craving in cocaine-dependent women. Overall, these results suggest that progesterone administration may be a useful intervention for reducing the incidence of relapse. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:183 / 189
页数:7
相关论文
共 57 条
[1]  
ANKER JJ, 2006, IN PRESS P 68 ANN M
[2]   Gender differences in stress reactivity among cocaine-dependent individuals [J].
Back, SE ;
Brady, KT ;
Jackson, JL ;
Salstrom, S ;
Zinzow, H .
PSYCHOPHARMACOLOGY, 2005, 180 (01) :169-176
[3]   ESTROUS CYCLE-DEPENDENT VARIATION IN AMPHETAMINE-INDUCED BEHAVIORS AND STRIATAL DOPAMINE RELEASE ASSESSED WITH MICRODIALYSIS [J].
BECKER, JB ;
CHA, JH .
BEHAVIOURAL BRAIN RESEARCH, 1989, 35 (02) :117-125
[4]   Gender differences in the behavioral responses to cocaine and amphetamine - Implications for mechanisms mediating gender differences in drug abuse [J].
Becker, JB ;
Molenda, H ;
Hummer, DL .
BIOLOGICAL BASIS OF COCAINE ADDICTION, 2001, 937 :172-187
[5]   Dopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking [J].
Berglind, WJ ;
Case, JM ;
Parker, MP ;
Fuchs, RA ;
See, RE .
NEUROSCIENCE, 2006, 137 (02) :699-706
[6]   ANXIOLYTIC EFFECT OF PROGESTERONE IS MEDIATED BY THE NEUROSTEROID ALLOPREGNANOLONE AT BRAIN GABA(A) RECEPTORS [J].
BITRAN, D ;
SHIEKH, M ;
MCLEOD, M .
JOURNAL OF NEUROENDOCRINOLOGY, 1995, 7 (03) :171-177
[7]   Gender differences in substance use disorders [J].
Brady, KT ;
Randall, CL .
PSYCHIATRIC CLINICS OF NORTH AMERICA, 1999, 22 (02) :241-+
[8]   A potential role for GABAB agonists in the treatment of psychostimulant addiction [J].
Brebner, K ;
Childress, AR ;
Roberts, DCS .
ALCOHOL AND ALCOHOLISM, 2002, 37 (05) :478-484
[9]   Effect of gonadectomy and gonadal hormone replacement on cocaine self-administration in female and male rats [J].
Caine, SB ;
Bowen, CA ;
Yu, G ;
Zuzga, D ;
Negus, SS ;
Mello, NK .
NEUROPSYCHOPHARMACOLOGY, 2004, 29 (05) :929-942
[10]   Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences [J].
Carroll, ME ;
Morgan, AD ;
Lynch, WJ ;
Campbell, UC ;
Dess, NK .
PSYCHOPHARMACOLOGY, 2002, 161 (03) :304-313