The Fate of Activated Group 2 Innate Lymphoid Cells

被引：21

作者：

Matha, Laura ^{[1
]}

Martinez-Gonzalez, Itziar ^{[2
]}

Steer, Catherine A. ^{[1
]}

Takei, Fumio ^{[1
,3
]}

机构：

[1] British Columbia Canc, Terry Fox Lab, Vancouver, BC, Canada

[2] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Solna, Sweden

[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

innate lymphoid cells; type; 2; inflammation; mucosal immunity; immunological memory; neonatal immunity; exhaustion; transdifferentiation; migration; TYPE-2; IMMUNITY; NASAL POLYPS; MEMORY; INDUCTION; INFECTION; RESIDENT; ILC2S;

D O I：

10.3389/fimmu.2021.671966

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Group 2 innate lymphoid cells (ILC2s) reside in both mucosal and non-mucosal tissues and play critical roles in the first line of defense against parasites and irritants such as allergens. Upon activation by cytokines released from epithelial and stromal cells during tissue damage or stimulation, ILC2s produce copious amounts of IL-5 and IL-13, leading to type 2 inflammation. Over the past 10 years, ILC2 involvement in a variety of human diseases has been unveiled. However, questions remain as to the fate of ILC2s after activation and how that might impact their role in chronic inflammatory diseases such as asthma and fibrosis. Here, we review studies that have revealed novel properties of post-activation ILC2s including the generation of immunological memory, exhausted-like phenotype, transdifferentiation and activation-induced migration.

引用

页数：11

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