The Fate of Activated Group 2 Innate Lymphoid Cells

被引：19
作者：
Matha, Laura [1 ]
Martinez-Gonzalez, Itziar [2 ]
Steer, Catherine A. [1 ]
Takei, Fumio [1 ,3 ]
机构：
[1] British Columbia Canc, Terry Fox Lab, Vancouver, BC, Canada
[2] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Solna, Sweden
[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
innate lymphoid cells; type; 2; inflammation; mucosal immunity; immunological memory; neonatal immunity; exhaustion; transdifferentiation; migration; TYPE-2; IMMUNITY; NASAL POLYPS; MEMORY; INDUCTION; INFECTION; RESIDENT; ILC2S;
D O I：
10.3389/fimmu.2021.671966
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Group 2 innate lymphoid cells (ILC2s) reside in both mucosal and non-mucosal tissues and play critical roles in the first line of defense against parasites and irritants such as allergens. Upon activation by cytokines released from epithelial and stromal cells during tissue damage or stimulation, ILC2s produce copious amounts of IL-5 and IL-13, leading to type 2 inflammation. Over the past 10 years, ILC2 involvement in a variety of human diseases has been unveiled. However, questions remain as to the fate of ILC2s after activation and how that might impact their role in chronic inflammatory diseases such as asthma and fibrosis. Here, we review studies that have revealed novel properties of post-activation ILC2s including the generation of immunological memory, exhausted-like phenotype, transdifferentiation and activation-induced migration.
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页数：11
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共 123 条
  • [1] IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
    Bal, Suzanne M.
    Bernink, Jochem H.
    Nagasawa, Maho
    Groot, Jelle
    Shikhagaie, Medya M.
    Golebski, Kornel
    van Drunen, Cornelis M.
    Lutter, Rene
    Jonkers, Rene E.
    Hombrink, Pleun
    Bruchard, Melanie
    Villaudy, Julien
    Munneke, J. Marius
    Fokkens, Wytske
    Erjefalt, Jonas S.
    Spits, Hergen
    Ros, Xavier Romero
    [J]. NATURE IMMUNOLOGY, 2016, 17 (06) : 636 - +
  • [2] ILC2s are the predominant source of intestinal ILC-derived IL-10
    Bando, Jennifer K.
    Gilfillan, Susan
    Di Luccia, Blanda
    Fachi, Jose L.
    Secca, Cristiane
    Cella, Marina
    Colonna, Marco
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 217 (02)
  • [3] IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction
    Barlow, Jillian L.
    Peel, Samantha
    Fox, Jane
    Panova, Veera
    Hardman, Clare S.
    Camelo, Ana
    Bucks, Christine
    Wu, Xiaoying
    Kane, Colleen M.
    Neill, Daniel R.
    Flynn, Robin J.
    Sayers, Ian
    Hall, Ian P.
    McKenzie, Andrew N. J.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (04) : 933 - 941
  • [4] Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity
    Barlow, Jillian L.
    Bellosi, Agustin
    Hardman, Clare S.
    Drynan, Lesley F.
    Wong, See Heng
    Cruickshank, James P.
    McKenzie, Andrew N. J.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (01) : 191 - U275
  • [5] Enhanced innate type 2 immune response in peripheral blood from patients with asthma
    Bartemes, Kathleen R.
    Kephart, Gail M.
    Fox, Stephanie J.
    Kita, Hirohito
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (03) : 671 - +
  • [6] IL-33-Responsive Lineage-CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs
    Bartemes, Kathleen R.
    Iijima, Koji
    Kobayashi, Takao
    Kephart, Gail M.
    McKenzie, Andrew N.
    Kita, Hirohito
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 188 (03) : 1503 - 1513
  • [7] c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
    Bernink, Jochem H.
    Ohne, Yoichiro
    Teunissen, Marcel B. M.
    Wang, Jingya
    Wu, Jincheng
    Krabbendam, Lisette
    Guntermann, Christine
    Volckmann, Richard
    Koster, Jan
    van Tol, Sophie
    Ramirez, Ivan
    Shrestha, Yashaswi
    de Rie, Menno A.
    Spits, Hergen
    Ros, Xavier Romero
    Humbles, Alison A.
    [J]. NATURE IMMUNOLOGY, 2019, 20 (08) : 992 - +
  • [8] Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population
    Bracamonte-Baran, William
    Chen, Guobao
    Hou, Xuezhou
    Talor, Monica V.
    Choi, Hee Sun
    Davogustto, Giovanni
    Taegtmeyer, Heinrich
    Sung, Jungeun
    Hackam, David Joel
    Nauen, David
    Cihakova, Daniela
    [J]. FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [9] Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
    Brestoff, Jonathan R.
    Kim, Brian S.
    Saenz, Steven A.
    Stine, Rachel R.
    Monticelli, Laurel A.
    Sonnenberg, Gregory F.
    Thome, Joseph J.
    Farber, Donna L.
    Lutfy, Kabirullah
    Seale, Patrick
    Artis, David
    [J]. NATURE, 2015, 519 (7542) : 242 - +
  • [10] IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
    Carriere, Virginie
    Roussel, Lucie
    Ortega, Nathalie
    Lacorre, Delphine-Armelle
    Americh, Laure
    Aguilar, Luc
    Bouche, Gerard
    Girard, Jean-Philippe
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (01) : 282 - 287
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