Establishment of the LNCaP Cell Line - The Dawn of an Era for Prostate Cancer Research

被引：24

作者：

Abate-Shen, Cory ^{[1
,2
,3
,4
]}

de Almeida, Francisca Nunes ^{[1
]}

机构：

[1] Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, Dept Mol Pharmacol & Therapeut, New York, NY USA

[2] Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, Dept Pathol & Cell Biol, New York, NY USA

[3] Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, Dept Syst Biol, New York, NY USA

[4] Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, Dept Urol, New York, NY USA

来源：

CANCER RESEARCH | 2022年 / 82卷 / 09期

关键词：

ANTIANDROGEN; RESISTANCE; BONE;

D O I：

10.1158/0008-5472.CAN-22-1065

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly in the context of androgen receptor signaling. Here, we present major highlights from a wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate cancer progression and androgen response for improving the treatment of patients with prostate cancer. ©2022 American Association for Cancer Research

引用

页码：1689 / 1691

页数：3

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