Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7

被引：1
|
作者：
Bauwens, Andreas [1 ]
Kunsmann, Lisa [1 ]
Karch, Helge [1 ,2 ]
Mellmann, Alexander [1 ,2 ]
Bielaszewska, Martina [1 ]
机构：
[1] Univ Munster, Inst Hyg, Munster, Germany
[2] Univ Munster, Interdisciplinary Ctr Clin Res IZKF, Munster, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 09期
关键词：
antibiotics; enterohemorrhagic E. coli; hemolytic uremic syndrome; outer membrane vesicles; Shiga toxins; HEMOLYTIC-UREMIC SYNDROME; SHIGA-TOXIN; PSEUDOMONAS-AERUGINOSA; STRAIN; INFECTION; OUTBREAK; GERMANY; RELEASE; RISK;
D O I：
10.1128/AAC.00937-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Ciprofloxacin, meropenem, fosfomycin, and polymyxin B strongly increase production of outer membrane vesicles (OMVs) in Escherichia coli O104:H4 and O157:H7. Ciprofloxacin also upregulates OMV-associated Shiga toxin 2a, the major virulence factor of these pathogens, whereas the other antibiotics increase OMV production without the toxin. These two effects might worsen the clinical outcome of infections caused by Shiga toxin-producing E. coli. Our data support the existing recommendations to avoid antibiotics for treatment of these infections.
引用
收藏
页数：5
相关论文
共 50 条
  • [31] Polysorbates prevent biofilm formation and pathogenesis of Escherichia coli O104:H4
    Sloup, Rudolph E.
    Cieza, Roberto J.
    Needle, David B.
    Abramovitch, Robert B.
    Torres, Alfredo G.
    Waters, Christopher M.
    BIOFOULING, 2016, 32 (09) : 1131 - 1140
  • [32] Persistence of Escherichia coli O157:H7 and Its Mutants in Soils
    Ma, Jincai
    Ibekwe, A. Mark
    Yi, Xuan
    Wang, Haizhen
    Yamazaki, Akihiro
    Crowley, David E.
    Yang, Ching-Hong
    PLOS ONE, 2011, 6 (08):
  • [33] Escherichia coli O104:H4 outbreak from sprouted seeds
    Soon, J. M.
    Seaman, P.
    Baines, R. N.
    INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2013, 216 (03) : 346 - 354
  • [34] Global transcriptional regulation by BirA in enterohemorrhagic Escherichia coli O157:H7
    Yang, Bin
    Jiang, Lingyan
    Wang, Shaomeng
    Wang, Lei
    FUTURE MICROBIOLOGY, 2018, 13 (07) : 757 - 769
  • [35] The conjugative transfer of plasmid-mediated mobile colistin resistance gene, mcr-1, to Escherichia coli O157:H7 and Escherichia coli O104:H4 in nutrient broth and in mung bean sprouts.
    Luo, Xin
    Matthews, Karl R.
    FOOD MICROBIOLOGY, 2023, 111
  • [36] The Worst of Both Worlds: Examining the Hypervirulence of the Shigatoxigenic/Enteroaggregative Escherichia coli O104:H4
    Steiner, Theodore S.
    JOURNAL OF INFECTIOUS DISEASES, 2014, 210 (12) : 1860 - 1862
  • [37] The ecological habitat and transmission of Escherichia coli O157:H7
    Chekabab, Samuel Mohammed
    Paquin-Veillette, Judith
    Dozois, Charles M.
    Harel, Josee
    FEMS MICROBIOLOGY LETTERS, 2013, 341 (01) : 1 - 12
  • [38] Lability of the pAA Virulence Plasmid in Escherichia coli O104:H4: Implications for Virulence in Humans
    Zhang, Wenlan
    Bielaszewska, Martina
    Kunsmann, Lisa
    Mellmann, Alexander
    Bauwens, Andreas
    Koeck, Robin
    Kossow, Annelene
    Anders, Agnes
    Gatermann, Soeren
    Karch, Helge
    PLOS ONE, 2013, 8 (06):
  • [39] Novel fusion protein protects against adherence and toxicity of enterohemorrhagic Escherichia coli O157:H7 in mice
    Gao, Xiang
    Cai, Kun
    Li, Tao
    Wang, Qin
    Hou, Xiaojun
    Tian, Renmao
    Liu, Hao
    Tu, Wei
    Xiao, Le
    Fang, Lihua
    Luo, Sen
    Liu, Yuenan
    Wang, Hui
    VACCINE, 2011, 29 (38) : 6656 - 6663
  • [40] Shiga toxin production and translocation during microaerobic human colonic infection with Shiga toxin-producing E. coli O157:H7 and O104:H4
    Seav-Ly Tran
    Billoud, Lucile
    Lewis, Steven B.
    Phillips, Alan D.
    Schueller, Stephanie
    CELLULAR MICROBIOLOGY, 2014, 16 (08) : 1255 - 1266
12345