Neurotransmitter changes in rat brain following acute alcohol intoxication

被引：1
作者：
Lelevich, S. V. [1 ]
Lelevich, V. V. [1 ]
Doroshenko, E. M. [1 ]
机构：
[1] Grodno State Med Univ, Grodno, BELARUS
来源：
NEUROCHEMICAL JOURNAL | 2010年 / 4卷 / 02期
关键词：
alcohol; brain; dopamine; serotonin; GABA;
D O I：
10.1134/S1819712410020091
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We studied the functional states of the main neurotransmitter systems in the brain following acute alcohol intoxication. Alterations in the contents of neurotransmitters, their metabolites, and neurotransmitter amino acids were the most prominent in the brainstem, thalamus, and neocortex following alcohol administration at doses of 2.5 or 5 g/kg. These alterations were observed in the key transmitters of the catecholaminergic system, such as dopamine, norepinephrine, and their metabolites. Following severe alcohol intoxication at a dose of 5 g/kg, the GABA level increased in the mentioned brain regions, showing a prevalence of inhibitory processes.
引用
收藏
页码：137 / 141
页数：5
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