A Review of the Evidence for Use of Thymoglobulin Induction in Renal Transplantation
被引:33
作者:
Gaber, A. Osama
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机构:
Methodist Hosp, Dept Surg, Methodist Transplant Ctr, Houston, TX 77030 USA
Weill Cornell Med Coll, New York, NY USAMethodist Hosp, Dept Surg, Methodist Transplant Ctr, Houston, TX 77030 USA
Depleting antilymphocyte, or antithymocyte antibodies, have long been an integral part of induction regimens and continue today to be used in the management of patients at risk of early rejection or those in whom the introduction of calcineurins or other immune suppressants must be delayed. Registry data demonstrate that the most commonly used depleting antibody, rabbit anti-human thymocyte globulin (rATG), is associated with improved outcomes following renal transplantation in high-risk patients, particularly in conjunction with steroid-avoidance regimens. Two prospective randomized trials in high-risk renal allograft patients have also demonstrated an advantage of r-ATG induction compared to the nondepleting interleukin receptor (IL2RA) antibodies. In low-immunologic-risk patients, however, r-ATG induction and IL2RA induction appear to be equivalent in terms of rejection prophylaxis and long-term function. Other studies have shown that sequential rATG-containing regimens were superior to no induction and allowed for successful late introduction of calcineurin inhibitors. The side effect profile of the depleting antibody included increased incidence of fever, hematologic abnormalities, cytomegalovirus infections when prophylaxis was not employed, and in some studies, increased incidence of posttransplant lymphoproliferative disease. This review describes the evidence supporting the use of depleting ATGs in kidney transplantation.
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Burke, George W.
;
Gaynor, Jeffrey J.
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机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Gaynor, Jeffrey J.
;
Roth, David
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机构:
Univ Miami, Leonard M Miller Sch Med, Dept Med, Div Nephrol, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Roth, David
;
Kupin, Warren
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h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Med, Div Nephrol, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Kupin, Warren
;
Rosen, Anne
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h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Rosen, Anne
;
Cordovilla, Tatiana
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机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Cordovilla, Tatiana
;
Tueros, Lissett
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h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Tueros, Lissett
;
Herrada, Eva
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机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Herrada, Eva
;
Miller, Joshua
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h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Miami VA Med Ctr, Miami, FL USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
机构:
Univ Missouri, Dept Pharm Practice, Kansas City, MO 64110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Hardinger, Karen L.
;
Rhee, Sunny
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机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Rhee, Sunny
;
Buchanan, Paula
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机构:
St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63103 USA
St Louis Univ, Ctr Outcomes Res, Sch Publ Hlth, St Louis, MO 63103 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Buchanan, Paula
;
Koch, Matt
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机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Koch, Matt
;
Miller, Brent
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机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Miller, Brent
;
Enkvetchakul, Decha
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机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Enkvetchakul, Decha
;
Schuessler, Rebecca
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机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Schuessler, Rebecca
;
Schnitzler, Mark A.
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机构:
St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63103 USA
St Louis Univ, Ctr Outcomes Res, Sch Publ Hlth, St Louis, MO 63103 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Schnitzler, Mark A.
;
Brennan, Daniel C.
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机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA USA
Issa, Nicolas C.
;
Fishman, Jay A.
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h-index: 0
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA USA
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Burke, George W.
;
Gaynor, Jeffrey J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Gaynor, Jeffrey J.
;
Roth, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Med, Div Nephrol, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Roth, David
;
Kupin, Warren
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Med, Div Nephrol, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Kupin, Warren
;
Rosen, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Rosen, Anne
;
Cordovilla, Tatiana
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机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Cordovilla, Tatiana
;
Tueros, Lissett
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h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Tueros, Lissett
;
Herrada, Eva
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Herrada, Eva
;
Miller, Joshua
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
Miami VA Med Ctr, Miami, FL USAUniv Miami, Leonard M Miller Sch Med, Dept Surg,Div Transplantat, Lillian Jean Kaplan Renal Transplant Ctr, Miami, FL 33101 USA
机构:
Univ Missouri, Dept Pharm Practice, Kansas City, MO 64110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Hardinger, Karen L.
;
Rhee, Sunny
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Rhee, Sunny
;
Buchanan, Paula
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63103 USA
St Louis Univ, Ctr Outcomes Res, Sch Publ Hlth, St Louis, MO 63103 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Buchanan, Paula
;
Koch, Matt
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Koch, Matt
;
Miller, Brent
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h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Miller, Brent
;
Enkvetchakul, Decha
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Enkvetchakul, Decha
;
Schuessler, Rebecca
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Schuessler, Rebecca
;
Schnitzler, Mark A.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63103 USA
St Louis Univ, Ctr Outcomes Res, Sch Publ Hlth, St Louis, MO 63103 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
Schnitzler, Mark A.
;
Brennan, Daniel C.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USAUniv Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA USA
Issa, Nicolas C.
;
Fishman, Jay A.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA USA