Drug-Eluting Versus Bare-Metal Stents in Unprotected Left Main Coronary Artery Stenosis A Meta-Analysis

被引：61

作者：

Pandya, Sanjay B. ^{[1
]}

Kim, Young-Hak ^{[2
]}

Meyers, Sheridan N. ^{[1
]}

Davidson, Charles J. ^{[1
]}

Flaherty, James D. ^{[1
]}

Park, Duk-Woo ^{[2
]}

Mediratta, Anuj ^{[1
]}

Pieper, Karen ^{[3
]}

Reyes, Eric ^{[3
]}

Bonow, Robert O. ^{[1
]}

Park, Seung-Jung ^{[2
]}

Beohar, Nirat ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Univ Ulsan, Coll Med, Seoul, South Korea

[3] Duke Clin Res Inst, Durham, NC USA

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2010年 / 3卷 / 06期

关键词：

unprotected; left main; coronary; intervention; LONG-TERM OUTCOMES; BYPASS GRAFT-SURGERY; ELEVATION MYOCARDIAL-INFARCTION; CARDIOLOGY-HOSPITAL RESEARCH; T-SEARCH REGISTRIES; MULTICENTER REGISTRY; CLINICAL-OUTCOMES; TAXUS-STENT; SURGICAL REVASCULARIZATION; PERCUTANEOUS TREATMENT;

D O I：

10.1016/j.jcin.2010.03.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives We undertook a meta-analysis to assess outcomes for drug-eluting stents (DES) and bare-metal stents (BMS) in percutaneous coronary intervention for unprotected left main coronary artery (ULMCA) stenosis. Background Uncertainty exists regarding the relative performance of DES versus BMS in percutaneous coronary intervention for unprotected left main coronary stenosis. Methods Of a total of 838 studies, 44 met inclusion criteria (n = 10,342). The co-primary end points were mortality, myocardial infarction (MI), target vessel/lesion revascularization (TVR/TLR), and major adverse cardiac events (MACE: mortality, MI, TVR/TLR). Results Event rates for DES and BMS were calculated at 6 to 12 months, at 2 years, and at 3 years. Crude event rates at 3 years were mortality (8.8% and 12.7%), MI (4.0% and 3.4%), TVR/TLR (8.0% and 16.4%), and MACE (21.4% and 31.6%). Nine studies were included in a comparative analysis (n = 5,081). At 6 to 12 months the adjusted odds ratio (OR) for DES versus BMS were: mortality 0.94 (95% confidence interval [CI]: 0.06 to 15.48; p = 0.97), MI 0.64 (95% CI: 0.19 to 2.17; p = 0.47), TVR/TLR 0.10 (95% CI: 0.01 to 0.84; p = 0.01), and MACE 0.34 (95% CI: 0.15 to 0.78; p = 0.01). At 2 years, the OR for DES versus BMS were: mortality 0.42 (95% CI: 0.28 to 0.62; p < 0.01), MI 0.16 (95% CI: 0.01 to 3.53; p = 0.13), and MACE 0.31 (95% CI: 0.15 to 0.66; p < 0.01). At 3 years, the OR for DES versus BMS were: mortality 0.70 (95% CI: 0.53 to 0.92; p = 0.01), MI 0.49 (95% CI: 0.26 to 0.92; p = 0.03), TVR/TLR 0.46 (95% CI: 0.30 to 0.69; p < 0.01), and MACE 0.78 (95% CI: 0.57 to 1.07; p = 0.12). Conclusions Our meta-analysis suggests that DES is associated with favorable outcomes for mortality, MI, TVR/TLR, and MACE as compared to BMS in percutaneous coronary intervention for unprotected left main coronary artery stenosis. (J Am Coll Cardiol Intv 2010;3:602-11) (C) 2010 by the American College of Cardiology Foundation

引用

页码：602 / 611

页数：10

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