The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species

被引：96

作者：

Iwase, M ^{[1
]}

Satta, Y

Hirai, Y

Hirai, H

Imai, H

Takahata, N

机构：

[1] Grad Univ Adv Studies, Dept Biosyst Sci, Kanagawa 2400193, Japan

[2] Kyoto Univ, Primate Res Inst, Inuyama, Aichi 4848506, Japan

[3] Natl Inst Genet, Mishima, Shizuoka 4118540, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 09期

关键词：

chromosomal rearrangement; evolutionary strata; recombination suppression;

D O I：

10.1073/pnas.0635848100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mammalian amelogenin (AMEL) genes are found on both the X and Y chromosomes (gametologous). Comparison of the genomic AMEL sequences in five primates and three other mammals reveals that the 5' portion of the gametologous AMEL loci began to differentiate in the. common ancestor of extant mammals, whereas the 3' portion differentiated independently within species of different mammals. The boundary is marked by a transposon insertion in intron 2 and is shared by all species examined. In addition, 540-kb DNA sequences from the short arm of the human X chromosome are aligned with their Y gametologous sequences. The pattern and extent of sequence differences in the 5' portion of the AMEL loci extend to a proximal region that contains the ZFX locus, and those in the 3' portion extend all the way down to the pseudoautosomal boundary (PAB)1. We concluded that the AMEL locus spans an ancient PAB, and that both the ancient and present PABs were determined by chance events during the evolution of mammals and primates. Sex chromosome differentiation likely took place in a region that contains the male-determining loci by suppressing homologous recombination.

引用

页码：5258 / 5263

页数：6

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