Hemospray for treatment of acute bleeding due to upper gastrointestinal tumours

被引：32

作者：

Arena, Monica ^{[1
]}

Masci, Enzo ^{[2
]}

Eusebi, Leonardo Henry ^{[3
]}

Iabichino, Giuseppe ^{[1
]}

Mangiavillano, Benedetto ^{[4
]}

Viaggi, Paolo ^{[1
]}

Morandi, Elisabetta ^{[1
]}

Fanti, Lorella ^{[5
]}

Granata, Antonino ^{[6
]}

Traina, Mario ^{[6
]}

Testoni, Pier Alberto ^{[5
]}

Opocher, Enrico ^{[7
]}

Luigiano, Carmelo ^{[1
]}

机构：

[1] San Paolo Hosp, Digest Endoscopy Unit, Via A Di Rudini 8, I-20142 Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Diagnost & Therapeut Endoscopy Unit, Milan, Italy

[3] St Orsola Hosp, Dept Med & Surg Sci, Gastroenterol & Endoscopy Unit, Bologna, Italy

[4] Gen Hosp Sanremo, Gastroenterol & Digest Endoscopy Unit, I-18038 San Remo, Italy

[5] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Div Gastroenterol & Gastrointestinal Endoscopy, Milan, Italy

[6] IRCCS ISMETT, Dept Diagnost & Therapeut Serv, Endoscopy Serv, Palermo, Italy

[7] Univ Milan, San Paolo Hosp, Dept Surg, Hepatobiliopancreat & Digest Surg Unit, Milan, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2017年 / 49卷 / 05期

关键词：

Hemospray; New endoscopic hemostatic treatment; Upper gastrointestinal cancer; Upper gastrointestinal neoplastic bleeding; HEMOSTASIS; EXPERIENCE; CANCER;

D O I：

10.1016/j.dld.2016.12.012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Hemospray is a new endoscopic haemostatic powder that can be used in the management of upper gastrointestinal bleedings. Aims: To assess the efficacy and safety of Hemospray as monotherapy for the treatment of acute upper gastrointestinal bleeding due to cancer. Methods: The endoscopy databases of 3 Italian Endoscopic Units were reviewed retrospectively and 15 patients (8 males; mean age 74 years) were included in this study. Results: Immediate haemostasis was achieved in 93% of cases. Among the successful cases, 3 re-bled, one case treated with Hemospray and injection had a good outcome, while 2 cases died both re-treated with Hemospray, injection and thermal therapy. No complications related to Hemospray occurred. Finally, 80% of patients had a good clinical outcome at 30 days and 50% at six months. Conclusion: Hemospray may be considered an effective and safe method for the endoscopic management of acute neoplastic upper gastrointestinal bleedings. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：514 / 517

页数：4

共 8 条

[1]

Blackshaw Guy R J C, 2004, Gastric Cancer, V7, P91

[2] Use of the endoscopically applied hemostatic powder TC-325 in cancer-related upper GI hemorrhage: preliminary experience (with video) [J].

Chen, Yen-I ;

Barkun, Alan N. ;

Soulellis, Constantine ;

Mayrand, Serge ;

Ghali, Peter .

GASTROINTESTINAL ENDOSCOPY, 2012, 75 (06) :1278-1281

[3] Long-term randomized controlled trial of a novel nanopowder hemostatic agent (TC-325) for control of severe arterial upper gastrointestinal bleeding in a porcine model [J].

Giday, S. A. ;

Kim, Y. ;

Krishnamurty, D. M. ;

Ducharme, R. ;

Liang, D. B. ;

Shin, E. J. ;

Dray, X. ;

Hutcheon, D. ;

Moskowitz, K. ;

Donatelli, G. ;

Rueben, D. ;

Canto, M. I. ;

Okolo, P. I. ;

Kalloo, A. N. .

ENDOSCOPY, 2011, 43 (04) :296-299

[4] Management of bleeding GI tumors [J].

Heller, Stephen J. ;

Tokar, Jeffrey L. ;

Nguyen, Minhhuyen T. ;

Haluszka, Oleh ;

Weinberg, David S. .

GASTROINTESTINAL ENDOSCOPY, 2010, 72 (04) :817-824

[5] The successful endoscopic hemostasis factors in bleeding from advanced gastric cancer [J].

Koh, Kang Hun ;

Kim, Kang ;

Kwon, Dae Hun ;

Chung, Bum Su ;

Sohn, Ji Youn ;

Ahn, Dae Seon ;

Jeon, Byung Jun ;

Kim, Seong Hun ;

Kim, In Hee ;

Kim, Sang Wook ;

Lee, Seung Ok ;

Lee, Soo Teik ;

Kim, Dae Ghon .

GASTRIC CANCER, 2013, 16 (03) :397-403

[6] Early experience with a novel hemostatic powder used to treat upper GI bleeding related to malignancies or after therapeutic interventions [J].

Leblanc, Sarah ;

Vienne, Ariane ;

Dhooge, Marion ;

Coriat, Romain ;

Chaussade, Stanislas ;

Prat, Frederic .

GASTROINTESTINAL ENDOSCOPY, 2013, 78 (01) :169-175

[7] ENDOSCOPIC TREATMENT OF MAJOR BLEEDING FROM ADVANCED GASTRODUODENAL MALIGNANT LESIONS [J].

LOFTUS, EV ;

ALEXANDER, GL ;

AHLQUIST, DA ;

BALM, RK .

MAYO CLINIC PROCEEDINGS, 1994, 69 (08) :736-740

[8] Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding [J].

Sung, J. J. Y. ;

Luo, D. ;

Wu, J. C. Y. ;

Ching, J. Y. L. ;

Chan, F. K. L. ;

Lau, J. Y. W. ;

Mack, S. ;

Ducharme, R. ;

Okolo, P. ;

Canto, M. ;

Kalloo, A. ;

Giday, S. A. .

ENDOSCOPY, 2011, 43 (04) :291-295

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