Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability

被引：23

作者：

Elmowafy, Mohammed ^{[1
,2
]}

Musa, Arafa ^{[3
,4
]}

Alnusaire, Taghreed S. ^{[5
]}

Shalaby, Khaled ^{[1
,2
]}

Fouda, Maged M. A. ^{[5
,6
]}

Salama, Ayman ^{[2
,7
]}

Al-Sanea, Mohammad M. ^{[8
]}

Abdelgawad, Mohamed A. ^{[8
,9
]}

Gamal, Mohammed ^{[10
]}

Fouad, Shahinaze A. ^{[11
]}

机构：

[1] Jouf Univ, Dept Pharmaceut, Coll Pharm, Sakaka 72341, Saudi Arabia

[2] Al Azhar Univ, Fac Pharm Boys, Dept Pharmaceut & Ind Pharm, Cairo 11765, Egypt

[3] Jouf Univ, Dept Pharmacognosy, Coll Pharm, Sakaka 72341, Saudi Arabia

[4] Al Azhar Univ, Dept Pharmacognosy, Fac Pharm, Cairo 11371, Egypt

[5] Jouf Univ, Dept Biol, Coll Sci, Sakaka 72341, Saudi Arabia

[6] Al Azhar Univ, Dept Zool, Fac Sci, Assiut 71511, Egypt

[7] Univ Tabuk, Dept Pharmaceut, Fac Pharm, Tabuk 47711, Saudi Arabia

[8] Jouf Univ, Dept Pharmaceut Chem, Coll Pharm, Sakaka 72341, Saudi Arabia

[9] Beni Suef Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Bani Suwayf 62514, Egypt

[10] Beni Suef Univ, Dept Pharmaceut Analyt Chem, Fac Pharm, Bani Suwayf 62514, Egypt

[11] Ahram Canadian Univ, Dept Pharmaceut, Fac Pharm, Giza 14756, Egypt

来源：

POLYMERS | 2021年 / 13卷 / 11期

关键词：

oleogel; skin delivery; quercetin; olive oil; PLURONIC LECITHIN ORGANOGEL; OXIDATIVE STRESS; TOPICAL DELIVERY; BLOCK-COPOLYMER; ANTIOXIDANT; FORMULATION; FLAVONOIDS; NANOPARTICLES; PENETRATION; PERMEATION;

D O I：

10.3390/polym13111808

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The main objective of this study was to prepare and characterize oleogel as potential carrier for quercetin skin delivery. The formulations were prepared by adding olive oil (5-30%) to Pluronic F127 hydrogel and were evaluated for particle size, zeta potential, viscosity in vitro quercetin release and stability, and were compared with that of Pluronic F127 hydrogel. The selected formulation was characterized for its interaction possibility, ex vivo skin permeation and skin histological changes and safety. The particle sizes ranged from 345.3 +/- 5.3 nm to 401.5 +/- 2.8 nm, and possessed negative charges. The viscosities of the formulations were found in the range of 6367-4823 cps with inverse proportionality to olive oil percentage while the higher percentages showed higher quercetin release. Percentages of 25% and 30% olive oil showed instability pattern under the conditions of accelerated stability studies. Differential scanning calorimetry verified the existence of quercetin in micellar aggregation and the network in the case of hydrogel and oleogel respectively. Ex vivo skin permeation showed an improved skin permeation of quercetin when 20% olive oil containing oleogel was used. Skin histology after 10 days of application showed stratum corneum disruption and good safety profile. Based on these findings, the proposed oleogel containing 20% olive oil denotes a potential carrier for topical delivery of quercetin.

引用

页数：14

共 52 条

[1] Preparation and Evaluation of Tubular Micelles of Pluronic Lecithin Organogel for Transdermal Delivery of Sumatriptan [J].