Heart Failure and Diabetes Mellitus: Defining the Problem and Exploring the Interrelationship

被引：0

作者：

Wilkinson, Michael J. ^{[1
]}

Zadourian, Adena ^{[1
]}

Taub, Pam R. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Cardiovasc Med, San Diego, CA 92103 USA

来源：

AMERICAN JOURNAL OF MEDICINE | 2019年 / 132卷 / 10期

关键词：

Cardiomyopathy; Diabetes mellitus; Heart failure; SGLT2; Type; 2; diabetes; UNITED-STATES; EJECTION FRACTION; PROGNOSTIC IMPACT; KETONE-BODIES; OUTCOMES; RISK; PREVALENCE; MORTALITY; GLUCOSE; EPIDEMIOLOGY;

D O I：

10.1016/j.amjmed.2019.08.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus and congestive heart failure are highly prevalent diseases with significant morbidity and mortality. These 2 diseases often occur concurrently because of shared risk factors such as coronary artery disease, and also because type 2 diabetes mellitus has direct cardiotoxic effects. Type 2 diabetes mellitus likely has a causative role in the development and prognosis of patients with heart failure. Optimal prevention and treatment of type 2 diabetes mellitus and heart failure likely involves identifying and treating their shared pathophysiologic features. Novel drug therapies, such as sodium-glucose co-transporter 2 inhibitors, offer an exciting potential to better understand the relationship between type 2 diabetes mellitus and heart failure, and may prove to have beneficial effects on cardiovascular outcomes in patients affected by these diseases. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：S3 / S12

页数：10

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