APP Receptor? To Be or Not To Be

被引：81

作者：

Deyts, Carole ^{[1
]}

Thinakaran, Gopal ^{[1
]}

Parent, Angele T. ^{[1
]}

机构：

[1] Univ Chicago, Dept Neurobiol, 924 East 57th St, Chicago, IL 60637 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2016年 / 37卷 / 05期

基金：

美国国家卫生研究院;

关键词：

AMYLOID PRECURSOR PROTEIN; INTRACELLULAR DOMAIN AICD; CELLULAR PRION PROTEIN; A-BETA PRODUCTION; REGULATED INTRAMEMBRANE PROTEOLYSIS; KINASE-INTERACTING PROTEIN-1; HEPARAN-SULFATE PROTEOGLYCAN; PROMOTES NEURITE OUTGROWTH; GAMMA-SECRETASE ACTIVITY; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.tips.2016.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amyloid precursor protein (APP) and its metabolites play a key role in Alzheimer's disease pathogenesis. The idea that APP may function as a receptor has gained momentum based on its structural similarities to type I transmembrane receptors and the identification of putative APP ligands. We review the recent experimental evidence in support of this notion and discuss how this concept is viewed in the field. Specifically, we focus on the structural and functional characteristics of APP as a cell surface receptor, and on its interaction with adaptors and signaling proteins. We also address the importance of APP function as a receptor in Alzheimer's disease etiology and discuss how this function might be potentially important for the development of novel therapeutic approaches.

引用

页码：390 / 411

页数：22

共 248 条

[1] Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase [J].

Abel, Ted ;

Nguyen, Peter V. .

ESSENCE OF MEMORY, 2008, 169 :97-115

[2] Not(ch) just development: Notch signalling in the adult brain [J].

Ables, Jessica L. ;

Breunig, Joshua J. ;

Eisch, Amelia J. ;

Rakic, Pasko .

NATURE REVIEWS NEUROSCIENCE, 2011, 12 (05) :269-283

[3] Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses [J].

Abramov, Efrat ;

Dolev, Iftach ;

Fogel, Hilla ;

Ciccotosto, Giuseppe D. ;

Ruff, Eyal ;

Slutsky, Inna .

NATURE NEUROSCIENCE, 2009, 12 (12) :1567-U120

[4] Megalin interacts with APP and the intracellular adapter protein FE65 in neurons [J].

Alvira-Botero, Ximena ;

Perez-Gonzalez, Rocio ;

Spuch, Carlos ;

Vargas, Teo ;

Antequera, Desiree ;

Garzon, Miguel ;

Bermejo-Pareja, Felix ;

Carro, Eva .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2010, 45 (03) :306-315

[5]

Ando K, 1999, J NEUROSCI, V19, P4421

[6] Novel cadherin-related membrane proteins, alcadeins, enhance the X11-like protein-mediated stabilization of amyloid β-protein precursor metabolism [J].

Araki, Y ;

Tomita, S ;

Yamaguchi, H ;

Miyagi, N ;

Sumioka, A ;

Kirino, Y ;

Suzuki, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (49) :49448-49458

[7] N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production [J].

Asada-Utsugi, Megumi ;

Uemura, Kengo ;

Noda, Yasuha ;

Kuzuya, Akira ;

Maesako, Masato ;

Ando, Koichi ;

Kubota, Masakazu ;

Watanabe, Kiwamu ;

Takahashi, Makio ;

Kihara, Takeshi ;

Shimohama, Shun ;

Takahashi, Ryosuke ;

Berezovska, Oksana ;

Kinoshita, Ayae .

JOURNAL OF NEUROCHEMISTRY, 2011, 119 (02) :354-363

[8] Presenilin-Dependent Receptor Processing Is Required for Axon Guidance [J].

Bai, Ge ;

Chivatakarn, Onanong ;

Bonanomi, Dario ;

Lettieri, Karen ;

Franco, Laura ;

Xia, Caihong ;

Stein, Elke ;

Ma, Le ;

Lewcock, Joseph W. ;

Pfaff, Samuel L. .

CELL, 2011, 144 (01) :106-118

[9] The in Vivo brain interactome of the amyloid precursor protein [J].

Bai, Yu ;

Markham, Kelly ;

Chen, Fusheng ;

Weerasekera, Rasanjala ;

Watts, Joel ;

Horne, Patrick ;

Wakutani, Yosuke ;

Bagshaw, Rick ;

Mathews, Paul M. ;

Fraser, Paul E. ;

Westaway, David ;

George-Hyslop, Peter St. ;

Schmitt-Ulms, Gerold .

MOLECULAR & CELLULAR PROTEOMICS, 2008, 7 (01) :15-34

[10] Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain [J].

Baumkoetter, Frederik ;

Schmidt, Nadine ;

Vargas, Carolyn ;

Schilling, Sandra ;

Weber, Rebecca ;

Wagner, Katja ;

Fiedler, Sebastian ;

Klug, Wilfried ;

Radzimanowski, Jens ;

Nickolaus, Sebastian ;

Keller, Sandro ;

Eggert, Simone ;

Wild, Klemens ;

Kins, Stefan .

JOURNAL OF NEUROSCIENCE, 2014, 34 (33) :11159-11172

← 1 2 3 4 5 6 7 8 9 10 →