Formal [4+2] Reaction between 1,3-Diynes and Pyrroles: Gold(I)-Catalyzed Indole Synthesis by Double Hydroarylation

被引：82

作者：

Matsuda, Yuka ^{[1
]}

Naoe, Saori ^{[1
]}

Oishi, Shinya ^{[1
]}

Fujii, Nobutaka ^{[1
]}

Ohno, Hiroaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 04期

基金：

日本学术振兴会;

关键词：

carbazoles; cascade reaction; gold catalysis; hydroarylation; indoles; HOMOGENEOUS GOLD CATALYSIS; ONE-POT SYNTHESIS; POLYCYCLIC COMPOUNDS; HYDROAMINATION; CONSTRUCTION; CASCADE; ALKYNES; CYCLIZATION; INHIBITORS; ALKALOIDS;

D O I：

10.1002/chem.201405903

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Indole synthesis by a gold(I)-catalyzed intermolecular formal [4+2] reaction between 1,3-diynes and pyrroles has been developed. This reaction involves the hydroarylation of 1,3-diynes with pyrroles followed by an intramolecular hydroarylation to give the 4,7-disubstituted indoles. This reaction can also be applied to the synthesis of carbazoles when indoles are used as the nucleophiles instead of pyrroles.

引用

页码：1463 / 1467

页数：5

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