La2O3/TFE: An efficient system for room temperature synthesis of Hantzsch polyhydroquinolines

被引：41

作者：

Tekale, Sunil U. ^{[1
]}

Pagore, Vijay P. ^{[1
]}

Kauthale, Sushama S. ^{[2
]}

Pawar, Rajendra P. ^{[2
]}

机构：

[1] Shri Muktanand Coll, Dept Chem, Gangapur 431109, India

[2] Deogiri Coll, Dept Chem, Aurangabad 431005, Maharashtra, India

来源：

CHINESE CHEMICAL LETTERS | 2014年 / 25卷 / 08期

关键词：

Hantzsch polyhydroquinolines; La2O3; TFE; ONE-POT SYNTHESIS; REUSABLE HETEROGENEOUS CATALYST; HIGHLY EFFICIENT; DERIVATIVES; CONDENSATION; FACILE; 1,4-DIHYDROPYRIDINES; CHEMISTRY; OXIDE;

D O I：

10.1016/j.cclet.2014.03.037

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lanthanum oxide (La2O3) in combination with 2,2,2-trifluoroethanol (TFE) was found to be an efficient system for the one-pot, four-component synthesis of Hantzsch polyhydroquinoline derivatives from aromatic aldehydes, dimedone, ethyl acetoacetate and ammonium acetate at ambient temperature. The catalyst is heterogeneous and reusable, hence can be separated easily and reused. The present method is featured by mild reaction conditions, use of heterogeneous catalyst, non-chromatographic purification, short reaction time and high yields, which make it an attractive route for the synthesis of polyhydroquinolines. (C) 2014 Rajendra P. Pawar. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1149 / 1152

页数：4

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