Case-control study of childhood acute lymphoblastic leukemia and residential radon exposure

被引:70
作者
Lubin, JH
Linet, MS
Boie, JD
Buckley, J
Conrath, SM
Hatch, EE
Kleinerman, RA
Tarone, RE
Wacholder, S
Robison, LL
机构
[1] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
[2] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA
[3] US EPA, Washington, DC 20460 USA
[4] Univ Minnesota, Sch Med, Div Pediat Epidemiol & Clin Res, Minneapolis, MN 55455 USA
来源
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1998年 / 90卷 / 04期
关键词
D O I
10.1093/jnci/90.4.294
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Several ecologic analyses have shown significant positive associations between mean indoor radon concentrations and risk of leukemia at all ages (acute myeloid leukemia and chronic lymphocytic leukemia) and for children (all leukemia, acute myeloid leukemia, and acute lymphoblastic leukemia [ALL]), As part of an age-matched, case-control study of childhood ALL in the United States, we investigated the association between the incidence of ALL in children under age 15 years and indoor radon exposure, Methods: Radon detectors were placed in current and previous homes of subjects where they resided for 6 months or longer, Children were included in analyses if radon measurements covered 70% or more of the 5-year period prior to diagnosis for case subjects (or from birth for case subjects under age 5 years) and the corresponding reference dates for control subjects, Radon levels could be estimated for 97% of the exposure period for the eligible 505 case subjects and 443 control subjects, Results: Mean radon concentration was lower for case subjects (65.4 becquerels per cubic meter [Bqm(-3)]) than for control subjects (79.1 Bqm(-3)), For categories less than 37, 37-73, 74-147, and 148 or more Bqm(-3) of radon exposure, relative risks based on matched case-control pairs were 1.00, 1.22, 0.82, and 1.02, respectively, and were similar to results from an unmatched analysis, There was no association between ALL and radon exposure within subgroups defined by categories of age, income, birth order birth weight, sex, type of residence, magnetic field exposure, parental age at the subject's birth, parental occupation, or parental smoking habits. Conclusions: In contrast to prior ecologic studies, the results from this analytic study provide no evidence for an association between indoor radon exposure and childhood ALL.
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页码:294 / 300
页数:7
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